Study On The Health Of The IVF-ET Offspirng Intervened By Traditional Chinese Medicine

Objective: Analysis the health of the IVF offspring that whose mother received invitro fertilization and embryo transfer(IVF-ET) that intervened by Traditional Chinesemedicine(TCM),and compared it with natural pregnancy epidemiological data.This canprovide safety evidence for the TCM used in assited reproductive technology(ART).Methods: Randomly selected120patients who received IVF-ET that intervened byTCM and successful gived birth to children during the period of November2001to March2006and June2009to March2013in the Reproductive and Genetic Center of IntegratedTraditional and Western Medicine of Affiliated Hospital of Shandong University ofTCM.The146example generation that were producted by the120cases of patients werethe research object. Through the record room query and telephone follow-up,collecttingTCM intervention IVF children’s situation that from born to the current,and established the“Table of offspring health after IVF-ET intervened by TCM”. Including birth weight,height of birth, sex, mode of production,1min Apgar score, neonatal diseases, incidencerate of premature birth, low weight, birth defects, the current body weight, height, diseasesituation, etc. To statistical processing of the collected data, and comparing with ournatural pregnancy epidemiological data.Results:In this study,Cesarean delivery rate is87.500%,the rate of premature birth is17.808%,were both greater than the natural pregnancy epidemiological data(35.3%,5%-15%);Congenital malformation children is2cases(1.370%),deformity rate higher thanthat of natural pregnancy epidemiological data on the value(1.307%),but there was nostatistically significant difference between the two deformity rate(P=0.94,P﹥0.05);Macrosomia is13cases (8.904%),the incidence of macrosomia on value is higherthan the natural pregnancy epidemiological data (7%),but there is no statistically significant difference (P﹥0.05).146offspring average birth weight is3143.240±614.831g,which is less than natural pregnancy epidemiological data, and the two groups havesignificant difference (P﹤0.05).TCM intervention IVF children preterm birth rates mayhave correlation with the rate of multiplets (0R39.43，95%CI8.77-177.28). The lowweight rate of TCM intervention IVF offspring could have correlation with the pretermbirth rate (0R39.55，95%CI11.17-140.03).The rest of the indicators did not seenobvious anomalies.Conclusion:1.TCM intervention IVF patients with cesarean section rate and the rateof preterm birth were both higher than the natural pregnancy epidemiological data. Therate of preterm birth has correlation with the rate of multiplets2.TCM intervention IVFoffspring congenital malformation rate is not higher than natural pregnancyoffspring.3.TCM intervention IVF children’s average birth weight is lower than the naturalpregnancy epidemiological data,but2to11years old children’s height and weight growthconditions are similar to natural pregnancy offspring.