Premenopausal Endometrial Cancer Clinical And Pathological Analysis

Endometrial cancer is in a group of endometrial epithelial malignant tumor, good haircrowd for postmenopausal women and perimenopausal women’s groups, the high-risk aged50-69years old. The disease is the most common female reproductive tract malignant tumors(about20-30%), each year about200000new cases of, and in some western countries, thedisease is higher than cervical cancer, cancer in the female reproductive system.Due to the extension of human life and the rise in obesity, the incidence of endometrialcancer rising in the world, and the trend of premenopausal the disease has increased. In ourcountry, along with the economic conditions improve, improvement of living index, thedisease has become the second female reproductive system tumor, second only to cervicalcancer, in growing. Although premenopausal endometrial cancer rates lower than inpostmenopausal women, but because the symptoms are not typical and clinical less easy tooverlook, determine the young female incidence of high-risk groups, clinical symptoms, thedetermination of the targeted help endometrial carcinoma patients, improve the earlydiagnostic rate.ObjectiveThe clinical and pathological features of patients with endometrial cancer beforemenopause，improve the rate of early clinical cure rate of early diagnosis.MethodBased on392cases of endometrial cancer in postmenopausal patients if the hospitalbetween2009and2014hospitalizations divided into premenopausal and postmenopausalgroups group, and its clinical features, tumor markers elevated conditions and pathologicalfeatures were retrospectively analysis.Results(50.2-7.2). No patients with postmenopausal group98cases (25%), has a trend of getting younger over. Two combination and hypertension, compared with difference was statisticallysignificant (P <0.05). Menopause tumor marker CA-125,HE4,CEA,CA19-9between thesurgical and pathological staging difference was not statistically significant.(P>0.05),pathological types in endometrial adenocarcinoma in the majority, clear cell carcinoma,plasma cells, times of two groups of comparison difference was statistically significantbetween clear cell carcinoma, pathologic differentiation degree is given priority to with grade1(high differentiation), level2(differentiation), level3(low differentiation), two groupscompare level3(low differentiation) between the difference was statistically significant.Scope of operation for removal of the uterus, attachment (bilateral) plus lymph nodecleaning/biopsy (pelvic/around the abdominal aorta), represented by comparison between thetwo groups in addition to the tumor cells to destroy the loss was statistically difference, otherno statistically significant differences in the scope of operation.ConclusionsPremenopausal endometrial carcinoma most for endometrial adenocarcinoma, don’t givepriority to with stage I, the types of tumor differentiation degree is high, fewer complications,less postoperative complications, especially less than45years old, the less risk factors,prognosis is good. Premenopausal and postmenopausal endometrial cancer tumor markers CA-125, HE–4, CEA,CA19-9have no obvious difference.