Available Jiuxinwan Clinical Observation For The Treatment Of Senile Hypertension Associated With Depression

Objective: to observe the quick-acting JiuXinWan for elderly patients withdepression with hypertension (grade1) intervention therapy, so as to elderly patients withdepression with hypertension (1) to provide a safe and effective drugs; And further studiesavailable JiuXinWan extension of the application.Methods: according to include and exclude standard screening senile hypertension(grade1) with60cases of depression. Single blind random divided into two groups, allgiven valsartan control of blood pressure, the treatment group is available JiuXinWantreatment group; Control group not taking other drugs,8weeks of treatment, respectivelyby radioimmunity method to check endothelial function (endothelin-ET, nitric oxide-NO,thromboxane-TXB2,6-alpha-6-K-ketone prostaglandin F1PGF1alpha), plasmaserotonin (5-HT) and interleukin6(IL6) and observation of blood pressure, Hamiltondepression rating scale, geriatric depression scale scores, clinical symptoms and so on.Results: treatment group total effectiveness83.3%, compared with the control group70%, with significant difference (P <0.05), the treatment group’s blood pressure,endothelial function, serotonin, interleukin-6, Hamilton depression rating scale, geriatricdepression scale scores, clinical symptoms were improved significantly.Conclusion: quick-acting JiuXinWan can by improving endothelial4, serotonin,interleukin-6obviously improve the old patients with hypertension associated withdepression, such as the clinical symptoms, reach the purpose of healing and is safe andeffective.