Vitamin D Intervention CAT Scores In Patients With Chronic Obstructive Pulmonary Disease And The Research On The Effects Of Inflammation In The Body

Objective This topic through the observation of chronic obstructive pulmonary disease(COPD) patients with plateau after adding exogenous vitamin D, inflammation in the body(IL- 17, IFN- gamma) pulmonary function and the change of the CAT scores, to explore the value of vitamin D in COPD stabilization treatment, for patients with COPD stabilization vitamin D supplements to provide some theoretical basis.MethodsSelection in March 2014 to August 2014 in our hospital clinic on stability of 60 cases of patients with COPD, randomly into control group and vitamin D treatment group(treatment group), 30 cases in each group. The control group: maintaining stabilization treatment for COPD patients, including oxygen, oral or inhaled bronchodilator; Treatment group: to maintain stability in patients with COPD treatment + capsule 0.25 mu of calcitriol g/d. Two groups oftreatment for a month. Using Elisa method respectively to detect the treatment group and control group before and after treatment serum 25(OH) D, IL- 17 and IFN- gamma levels. Also detected in the two groups before and after treatment in patients with chronic obstructive pulmonary disease assessment test score marks(CAT), analysis and comparison before and after treatment serum 25(OH) D and inflammation factors and the correlation between the CAT score.Results1.Vitamin levels before treatment group and control group were 27.35±8.92, 26.41±7.38; There was no significant difference between the two groups(P > 0.05). Vitamin D supplements after treatment, the treatment group of 25(OH) D level don’t was 33.45±9.04, significantly higher than that before treatment(P < 0.05), the control group after treatment of 25(OH) Dlevel was 24.52 ± 7.60, compared before and after no significant change(P > 0.05), vitamin D after the intervention treatment group of 25(OH) D level was more significantly increased(P < 0.05).2.Treatment group and control group before the CAT scores were 17.80±4.14, 17.80±3.99, no significant difference between the two groups(P > 0.05), the treatment group after vitamin D supplements, CAT score was 15.53±2.79, compared with the previous decreases obviously, the difference was statistically significant(P < 0.05); The control group after treatment the CAT score was 14.30±4.06, no significant changes before and after contrast, there was no statistically significant difference(P > 0.05). Vitamin D after the intervention treatment group compared with control group, the CAT scores have significant difference(P < 0.05).3.Treatment group and control group before the CAT scores were 17.80±4.14, 17.80±3.99, no significant difference between the two groups(P >0.05), the treatment group after vitamin D supplements, CAT score was 15.53±2.79, compared with the previous decreases obviously, the difference was statistically significant(P < 0.05); The control group after treatment the CAT score was 14.30±4.06, no significant changes before and after contrast, there was no statistically significant difference(P > 0.05). Vitamin D after the intervention treatment group compared with control group, the CAT scores have significant difference(P < 0.05).4.Treatment group and control group before treatment the serum level of IFN- gamma 32.19±10.85, 10.85±12.67, no significant difference between the two groups(P > 0.05), and vitamin D supplements, the treatment group patients was 29.75±11.21 serum levels of IFN- gamma, apparent decline in earlier, statistically significant difference(P < 0.05); The control group after treatment was 32.35±11.36, serum levels of INF-gamma has no obvious change before and after contrast, there was no statistically significant difference(P > 0.05). Vitamin D after the intervention treatment group compared with controls serum IFN- gamma significant differences(P < 0.05).5.Treatment group and control group before treatment serum 25(OH) D level and negatively correlated with the CAT score(r = 0.315, P = 0.014).6.Treatment group and control group before treatment serum 25(OH)D level and inflammation in the body factor IL-17 concentration showed a negative correlation(r = 0.265, P = 0.041).7.Treatment group and control group before treatment serum 25(OH) D3 level and inflammation in the body factor IFN- gamma density showed a negative correlation(r =- 0.371, P = 0.03). Conclusion1.Exogenous vitamin D supplements can make the plateau COPD patients serum 25(OH) D level.2.Vitamin D supplements may reduce plateau COPD patient CAT scores, after after the exogenous vitamin D supplement helps to improve and improve the patients quality of life.3.Vitamin D supplements can lower the levels of IL-17、IFN-γ plateau COPD patients, prompt supplement exogenous vitamin D supplementation after reducing the CAT scores, improve and improve the patients quality of life, and its possible mechanism by downgrade IL-17、IFN-γexpression, so as to reduce inflammation reaction.