The Clinical Value For Detection Of Serum Vitamin D In Patients With Chronic Obstructive Pulmonary Disease

Objection:Serum 25-hydroxyvitamin D, which is the main substance of vitamin D in peripheral blood circulation, are measured in the paitents with chronic obstructive pulmonary disease(COPD), as well the forced expiratory volume in 1 second(FEV 1). The clinic relationship between serum vitamin D and COPD are discussed..Material:All the individuals were prospectively recruited at the Shandong Provincial Hospital, of which,according to the pulmonary function measurements,79 patients with COPD are devided as observation group,52 healthy smokers as control group. All subjects the underwent pulmonary function tests, and according to the latest initiative of Global Initiative for Chronic Obstructive Lung Disease (GOLD) are divided into mild, moderate, severe and very severe. Factors such as age, gender, body mass index and smoking index are collected in the questionnaires.Result:1. Baseline characteristics of the study population.The different in age, sex distribution, body mass index, smoking index between The two groups has no significant(P>0.05). The serum 25-OHD in COPD group is 49.55±8.63) mmol/L,and (61.58±8.77) mmol/L in the control group. The di-fference was statistically significant (P<0.05).2. Level of the 25-OHD and FEV1% predictedThe FEV1% predicted in COPD group is (60.33±4.12)%, and (86.26±3.41) %in the control group. The relationship of serum 25-OHD and FEV1% predicted in the two group has significantly difference(Pearson r=0.23, P<0.05).3.Vitamin D and the severity of COPD.According to the GOLD,79 patients are devided in to four groups:mild(n=21) moderate(n=25), severe(n=22) and very severe(n=11).Compared to the control group the difference in the mild group has no significant(P>0.05). And from GOLD 2 onwards,25-OHD levels differed significantly from those of healthy smokersConclusion1. Vitamin D deficiency is highly prevalent in patients with COPD and correlates with the severity significantly.2. Compared to the healthy smokers, patients with COPD are easily to suffer vitamin D deficiency.3. Serum 25-OHD is positivly correlated with the FEV1% predicted. Serum 25-OHD may effect the pulmonary function in patiants with COPD.