Correlation Between Vitamin D And Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective: To understand the level of serum vitamin D in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD),to explore the level of serum vitamin D and lung function,quality of life in patients with AECOPD,the number of acute exacerbations in one year 1.The correlation of inflammatory factors in vivo provides new ideas for the prevention and treatment of AECOPD.Methods: According to the inclusion and exclusion criteria,75 AECOPD patients hospitalized in the Department of Respiratory and Critical Care of Shaanxi Provincial People's Hospital from October 2019 to January 2020 were collected as the AECOPD group,and divided into vitamin D normal groups according to vitamin D content3 There were 12 cases of vitamin D insufficiency group,22 cases of vitamin D deficiency group and 38 cases of severe vitamin D deficiency group;40 healthy control groups were collected at the same time in the physical examination center of Shaanxi Provincial People's Hospital.Collect the basic information about the age,sex,body mass index(BMI)and smoking history of all patients included in the study.Collect the 25-(OH)D levels of all the included investigators,and collect the lung function(FEV1 /% pred,FEV1 / FVC),CAT score,the number of exacerbations in the previous year,N%,hs-CRP,IL-6.IL-8.Compare the prevalence of vitamin D deficiency in patients in AECOPD group and healthy control group;compare the differences in lung function,CAT score,inflammation indicators,etc.of patients with different 25-(OH)D levels in AECOPD group,and explore the correlation between vitamin D and AECOPD patients Sex.Results: 1.There is no statistical difference in general data such as age,sex,smoking and body mass index between the AECOPD group and the non-COPD group(P> 0.05),and the two groups are comparable;the AECOPD group is based on 25-(OH)D level is divided into normal serum vitamin D group,vitamin D insufficiencygroup,vitamin D deficiency group,and vitamin D extreme deficiency group.There is no statistical difference in age,gender,smoking and body mass index among the four groups(P > 0.05),comparable.2.Of the 75 patients in the AECOPD group,60 were in vitamin D deficiency,with a prevalence rate of 80%;a total of 40 healthy controls,including 19 in vitamin D deficiency,with a prevalence rate of 47.5%,in both groups The overall prevalence of the prevalence is different,and the difference is statistically significant(2 = 9.941,P <0.05).3.75 patients in the AECOPD group were divided into four groups according to the content of vitamin D: normal vitamin D group,insufficient vitamin D group,vitamin D deficiency group,and extreme vitamin D deficiency group.A single factor analysis of variance was conducted between the four groups for FEV1% pred Statistically significant(P <0.05);single factor analysis of variance for FEV1 / FVC among the four groups was not statistically significant;single factor analysis of variance for CAT scores among the four groups was statistically significant(P <0.05);Pearson correlation analysis,vitamin D levels in the AECOPD group were positively correlated with FEV1% pred(r = 0.377,P = 0.001),the lower the vitamin D level,the lower the FEV1% pred;There was a negative correlation(r =-0.377,P = 0.001).The lower the vitamin D level,the higher the CAT score and the worse the quality of life of the patients.4.Compared with the number of acute exacerbations within 1 year among the four groups of normal vitamin D,vitamin D deficient,vitamin D deficient,and vitamin D deficient groups,the results showed no significant difference(P> 0.05).5.The four groups of normal vitamin D group,vitamin D deficient group,vitamin D deficient group,and vitamin D deficient group were analyzed by variance analysis with inflammation index N%,hs-CRP,IL-6,IL-8,the results suggest that each The differences of N%,hs-CRP,IL-6 and IL-8 between the groups were statistically significant(P <0.05).Pearson correlation analysis was performed for further comparison.The results showed that the serum 25(OH)D concentration andgranulocyte ratio(r =-0.245,P = 0.034),hs-CRP(r =-0.357,P = 0.002)And IL-6(r =-0.369,P = 0.001)were negatively correlated,and had no correlation with IL-8(r =-0.178,P = 0.126).Conclusion: 1.The prevalence of vitamin D deficiency in AECOPD patients is higher than that in healthy controls.2.Serum vitamin D level is related to the lung function and quality of life of AECOPD patients.The higher the vitamin D level,the better the lung function and quality of life.3.Vitamin D can affect the inflammatory response in the body,can reduce the N%,IL-6,hs-CRP content of AECOPD patients,reduce the inflammatory response in the body.