| Background The Primary Hepatic Squamous Cell Carcinoma (PSCCL) is a rare malignant liver lesions clinically, there are three main characteristics:the progress of fast speed, the high degree of malignancy, and the high rate of misdiagnosis. With the rapid development of imaging and pathology technology, this disease was reported increasingly, and about 100 cases were reported domestic and abroad, but were all case reports, no systematic summary on the diagnosis and treatment of this disease.This study is focused on the clinical practice, to summarize the clinical data of PSCCL patients reported by domestic and abroad ,in order to provide reference for the clinical diagnosis and treatment, and improve the understanding of this disease for clinicians.Objective To study the Primary Squamous Cell Carcinoma of the Liver (PSCCL) clinically and imaging features, etiology and prognosis of choice, the tissue of origin, pathology, diagnosis, differential diagnosis, treatment, to improve the understanding, diagnosis and treatment level of the PSCCL.Methods In this study, "liver", "liver cancer", "liver placeholder", "squamous cell carcinoma", "Diagnostics", "treatment"were searched in China CNKI, VIP News Chinese scientific journals database, and Wan Fang DATA published in 1982-2013.Unified inclusion and exclusion criteria。 Combined with the 2 cases diagnosed and treated in our hospital from 2009 to 2010,collecting and analyzing all the literature synthetically。Results (1) The paper retrieved 44 literature, and 48 cases were accord with standard, including 28 males and 20 females, average age:55.7+0.4 years. (2) there were no rules to follow for patients of the treatment of symptoms, mainly pain on the left upper quadrant fever, chills, left upper quadrant mass and other non-specific symptoms . Imaging diagnosis had little significance about this disease, defined it mainly on pathology and immunohistochemistry. (3) From above findings,we could find PSCCL may be related to the liver cysts and bile duct stone’s occurrence, comparing to the patient’s own sex, age, presence or absence of hepatitis, liver cirrhosis and its own habits:smoking, drinking and other factors, no significant difference (P> 0.05). (4)The antigen and CA19-9 of patients with squamous cell PSCCL increased significantly, which had relationship with the length of survival and significant difference statistically (P<0.05), but not related to CA125, CEA and AFP (P> 0.05). (5) Prognosis and tumor size of PSCCL, number, vascular invasion or no, analyzed and compared with the survival time statistically existing significant difference (P<0.05); comparing the choice surgery measure with survival length, having statistically significant difference (P<0.05); gender, age, smoking, drinking, race, carrying hepatitis and cirrhosis of the liver and other factors and survival relationship, lacking significant difference (P> 0.05). (6) compared surgical (resection), tumor size, lymph node metastasis number with length of survival after univariate analysis, exiting statistically significant difference (P<0.05).Conclusionst Etiology PSCCL might have relationship to liver cysts and bile duct stones, no specific clinical features, imaging can only help diagnose but can not be confirmed, serum squamous cell antigen and CA19-9 have diagnostic significance, can be used for monitoring. Treatment of this disease is majoring in surgery combined therapy, and surgical approach had a large influence on prognosis. |
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