3.0T MRI Susceptibility-Weighted Imaging Clinical Study On Cerebral Microbleeds In Type 2 Diabetes And Association With Cognitive Function

Objective Purpose: In the study, we used as biological markers of cerebral microbleeds to study the microvascular disease of diabetic encephalopathy, analysis of microbleeds situation and explore the cognitive dysfunction in diabetic. Methods: We recruit patients with type 2 diabetes with cognitive dysfunction evaluated by Montreal Cognitive Scale(Mo CA) in 30 cases, and patients with type 2 diabetes, having non-recognition dysfunction in 30 cases, which matches by General Information. Each test subject’s Mo CA total score and the score decile was recorded. Then underwent conventional MRI and SWI scan. The distribution and the number performed of cerebral microbleeds(CMBs) on SWI were recorded. Using SPSS 17.0 to analyze the differences between the two groups of CMBs probability of occurrence and number. Then according to the number of CMBs, comparing the difference of Mo CA total score and the score decile between different grades CMBs. Results: 60 met the inclusion criteria, but three cases that MRI examination found obvious white matter hyperintensities and lacunar infarction were removed. Eventually enrolled subjects were 57 cases. CMBs were found 26 cases in all 57 cases. CMBs prevalence rate was 45.6%. In total 155 CMBs, the number and distribution of cerebral microbleeds were common in subcortical / cortical areas, subcortical / cortical areas CMBs were 107, lower hemisphere deep CMBs were 41, brainstem and curtain CMBs were 7, accounting for the total respectively 69.0%, 26.5%, 4.5%. There were 8 CMBs positive cases in normal cognitive group, found CMBs 28(subcortical / cortical 7 cases 19 CMBs, hemisphere deep 2 cases 7 CMBs, brainstem and infratentorial 1 case 2 CMBs), that CMBs grade 1 were 6 cases, CMBs grade 2 were 2 cases; cognitive dysfunction group were 28 cases, 18 CMBs positive cases were found CMBs 127(subcortical / cortical 16 cases 88 CMBs, hemisphere deep 8 cases 34 CMBs, brainstem and infratentorial 2 cases 5 CMBs), that CMBs grade 1 were 8 cases, CMBs grade 2 were 7 cases, CMBs grade 3 were 3 cases. The two groups had significant difference in the number and case of CMBs(P<0.05). The two groups had significant difference in the case of CMBs in difference area of brain(P<0.05). The total Mo CA scores, visuospatial skills and execution function scores, nomenclature scores, attention scores, language scores, abstracting scores, memory scores and directive force scores in CMBs group were significantly lower than those in CMBs group 0(P<0.05). According to Spearman correlation analysis results, the CMBs number was negatively correlated with total Mo CA scores, visuospatial skills and execution function scores, attention scores, language scores, abstracting scores and memory scores(P<0.05), but were not correlated with naming and capabilities scores(P>0.05). Conclusion: 1. Probability of occurrence of CMBs in Diabetes of cognitive impairment was significantly higher than normal cognitive diabetic group, the number of CMBs was significantly higher than normal cognitive group; 2. Diabetes cerebral microbleeds distributed to subcortical / cortical-based, we hypothesized that diabetic microangiopathy and CAA potentially relevant; 3. The number of diabetic cerebral microbleeds and Mo CA scores were negatively correlated, we believe that the greater the number of patients with cerebral microbleeds have more severe cognitive impairment trend.