Three-dimensional Power Doppler Angiography Characteristics And Its Quantitative Parameters In The Diagnosis Of Thyroid Carcinoma

Objective: To evaluate the application of three-dimensional color power angiography (3D-CPA) and its quantitative parameters in the diagnosis of benign and malignant thyroid nodules. Method:Eighty-five thyroid nodules were examined by using GE Logiq E9 with the VOCAL software. Meanwhile we obtained the histogram and the quantitative index:Mean Gray (MG), vascularization flow index (VFI), mean power (MP), ratio (R). The receiver operating characteristics (ROC) curves were performed. We compared the areas under ROC curves (AUC) of the three-dimensional gray-scale ultrasound and three-dimensional power doppler angiography, confirmed the best cutoff point of the thyroid nodules diagnosis. We also assess the sensitivity and specificity of the two methods. Finally, we used Z test to determine whether the difference between the two methods was significant. Results:The differences between benign and malignant thyroid nodules in 3D-CPA and their parameters were significant (P<0.05); To diagnose benign and malignant nodules, the area under the ROC curve of the MG and MP were 0.845 and 0.725, respectively. The value of MG and MP were combined to diagnose benign and malignant nodules, and the area under the ROC curve was 0.848, which was the highest value in diagnosing. Conclusions:There were significant differences between MG and MP in benign and malignant hypoechoic solid nodules measured by 3D-CPA quantitative analysis, which could improve the diagnostic accuracy and precision for thyroid nodules.