Association Between Chronic Periodontitis And Vitamin D Receptor Gene Polymorphisms Among Uygur Adults In Moyu County Of Xinjiang

Objective: To investigate the association of vitamin D receptor(VDR) gene Bsm I and TaqI polymorphisms with chronic periodontitis(CP) among Uygur adults in Moyu county of Xinjiang. Methods: The buccal swabs of 185 subjects were randomly selected from epidemiological investigation of Uygur adults in Moyu county in April and May 2013, including 95 patients of CP and 90 healthy controls. VDR Bsm I, TaqI were tested with polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) to investigate the association between VDR gene polymorphism and CP. Results: There was statistically significant difference in the frequencies of VDR BsmI genotypes and alleles between the CP patients and healthy controls(P=0.016, P=0.003). There was no statistically significant difference in the frequencies of VDR TaqI genotypes and alleles between two groups. Chronic periodontitis and healthy controls only show significant difference in VDR BsmI allele frequencies in male and female. The one way logistic analysis manifests that bb genotype and allele b may be the risk factors of CP. Conclusion: The susceptibility to chronic periodontitis among Uygur adults in Moyu county of Xinjiang is related to the Bsm I polymorphism of VDR gene, the bb genotype and allele b might be the susceptibility factors in the chronic periodontitis of Uygur adults.