The Relationship Between Methylation Of BDNF Gene Promoter Region And Primary Depression Patients With Or Without Suicide Ideas

Objective:To investigate the effects of methylation of BDNF gene promoter region in depression onset. To discuss the correlation between methylation of BDNF gene promoter region and primary depression patients with or without suicide ideas. Methods:Peripheral blood from 23 depressed patients with suicide ideas,24 depressed patients without suicide ideas and 27 normal subjects of control group was respectively served as objects of study. BDNF gene promoter region’s CpG islands methylation was tested using bisulfite sequencing. Results:The results after comparing among three groups were significantly different. The difference had statistical significance (P<0.05). By pairwise comparison, the difference between depression with suicide group and depression without suicide group had no statistically significant. Pairwise comparison showed the methylation level in the mean rank depression with suicide group was higher than that of control group. The difference had statistical significance (P<0.017). The mean methylation level in the depression without suicide group was higher than that of control group. The difference had statistical significance (P<0.017). Conclusion:The methylation level of BDNF gene promoter region is related to depression onset but not related to with or without suicide ideas in depression patients.