| Objective:Research Uygur, Han nationality patients with first-episode depression of serum Hey levels and the relationship between cognitive function and P300. Methods: Select 119 cases of first episode depression patients(case group) and 117 cases of healthy volunteers(healthy control group), serum Hey levels between the two groups by enzyme-linked immunosorbent assay, assessment of cognitive function selection MoCA scale, Using brain master system to complete the P300 evoked potential testing. Results: Compared to the control group, the patient group elevated serum Hey levels, P3 latency, amplitude decreased, MoCA scale score is low, the differences were statistically significant(P<0.05 or P<0.001). Case group HHcy group than non HHcy group P300 latency and amplitude decreased, MoCA scale score lower, HAMD-24 scale score higher, the difference was statistically significant(P<0.05 or P<0.001). Patients with serum Hey levels HAMD-24 score was positively correlated with the P3 latency was positively correlated with the target P3 amplitudewas negatively correlated with MoCA scale scores were negatively correlated statistically significant(P<0.05 or P<0.001). Conclusion:The first episode of depression in patients with cognitive dysfunction, Hey metabolic imbalance associated with cognitive impairment in patients with depression, these differences and nationalities no certain relationship. |
