Effects Of Computer Aided Cognitive Training On Cognitive Function And P300 In Patients With Non - Dementia Vascular Cognitive Impairment

Objective Discuss the effect of computer-aided cognitive training on cognitive function in patients with vascular cognitive impairment no dementia(VCIND) and auditory event-related potential P300.Methods 60 patients with vascular cognitive impairment no dementia were randomly divided into two groups: training group and control group.Each group have 30 patients. Two groups were given routine drug treatment and the traditional rehabilitation training.At the same time,the training group were given computer-aided cognitive training: 40min/time,1/day,6/week,4weeks of treatment.Respectively, before and after four weeks of treatment,useing mini-mental state examination(MMSE)、the Montreal cognitive assessment(Mo CA)、 Barthel Index(BI)、Motor evoked potential instrument assessed the cognitive function of the two groups、the ability of daily life(ADL)、 P300.Results Before treatment,the comparison of Mo CA、MMSE and BI scores of two groups were no statistically significant difference(P>0.05).Compared with before treatment,the total Mo CA scores、visual space and executive function、attention、language、delayed memory、MMSE and Barthel Index scores of two groups were increased after treatment(P<0.05).After treatment,compared with control group, the total Mo CA scores、visual space and executive function、attention、language、delayed memory、MMSE and BI scores of the training group were improved obviously(P<0.05).Before treatment,the comparison of P300 latency and amplitude of two groups were no statistically significant difference(P>0.05).Compared with before treatment,P300 latency of two groups was shorten obviously( P < 0.05) and amplitude was heighten( P < 0.05). After treatment,compared with control group,P300 latency of the training group was shorten and amplitude was heighten.Difference are statistically(P<0.05).Conclusion computer-aided cognitive training can effectively improve the cognitive function of patients with VCIND, improving daily life ability of patients.