Association Between Serum Vitamin D And Cardiovascular Disease Risk Factors Of Uygur And Han Adults

Objective:Vitamin D deficiency was widespread health problem associated with increased risk of cardiovascular diseases. This study aims to identify vitamin D nutritional status and associations with cardiovascular disease risk factors of Uygur and Han adults in Xinjiang, to provide clinical basis for the prevention and control of cardiovascular disease. Methods:A cross-sectional survey was performed in 2 251 residents in Xinjiang Urumqi from May 2013, including Uygur 812, Han 1 046 adults for medical examinations and questionnaires, to determine biochemical indicators. The statistical method of correlation and regression analysis were applied to explore the relationship of serum vitamin D levels and cardiovascular risk factors of Uygur and Han adults. Results:(1) Compared related indicators of vitamin D deficiency with non deficiency, Uygur women accounted for the highest vitamin D deficiency (92.2%). In Han:SBP, HbAlc, FPG, TC, UA, smoking and low activity of vitamin D deficiency populations were significantly higher than those of non deficiency; in Uygur:WC, TC, TG, LDL-C, UA, smoking and low activity of vitamin D deficiency were higher than those of the lack. Vitamin D deficiency was negatively correlated with age (elderly population began to rise), but was unrelated to BMI; (2) Correlation analysis showed that 25-(OH)D was associated with age, gender, smoking, activity degree. Controlled the above factors and drugs history,25-(OH)D had negative correlation with SBP, HbAlc, FPG, TC, TG, UA, only DBP, LDL-C correlated negatively in Uygur; Logistic regression analysis showed that 25-(OH)D levels were significantly associated with hypertension, hyperglycemia and hyperuricemia in Han, were significantly associated with abdominal obesity, dyslipidemia and hyperuricemia in Uygur(P<0.05); (3)By controlling for age, BMI, smoking and activity,25-(OH)D levels and Framingham score showed no correlation no matter men and women. Conclusion: Both Uygur and Han adults had vitamin D deficiency generally in Xinjiang, especially in Uygur women, which was negatively correlated with age.25-(OH)D level was related with age, gender, smoking, exercise, blood pressure, glucose and lipid metabolism, uric acid indexes, had significant ethnic differences associated with cardiovascular disease risk factors. The serum 25-(OH)D level as a clinical index to predict and evaluate some cardiovascular risk factors, will has a certain clinical value.