Study On The Relationship Between Vitamin D Deficiency And Cardiovascular Disease In Elderly Inpatients In Qingdao

OBJECTIVE To investigate the vitamin D deficiency in hospitalized patients over 60 yrs in Qingdao; To explore the relationship of vitamin D deficiency with cardiovascular complication and its risk factors in type 2 diabetes mellitus patients over 60 yrs.METHODS Between Nov. 2014 to Apr. 2015, the serum 25(OH)D levels of 1,821 in-patients in The Affiliated Hospital of Qingdao University were tested and recorded. The patients were allocated into different groups according to age?gender and 25(OH)D levels and inter-group difference in between groups 25(OH)D level was analyzed by SPSS19 software.94 type 2 diabetes mellitus patients aged over 60 yrs were chosen to explore the relationship of vitamin D deficiency with cardiovascular complication and its risk factors. The general health condition, medical history and laboratory indicators were collected. The patients were allocated into different groups according to complications?diabetes course and 25(OH)D levels. Multiple logistic regression analysis was used to analyze the correlation between 25(OH)D levels and incidence of cardiovascular complication while Pearson analysis was used to analyzed the correlation between 25(OH)D levels and cardiovascular risk factors.RESULTS The incidence rate of VD deficiency was 88.75% in man and 87.87% in women. The serum 25(OH)D levels was slightly lower in man than in women, although the difference was not statistically significant(P=0.367>0.05). In terms of age, the serum 25(OH)D levels was significantly lower in older patients(p=0.006<0.01). In addition, 25(OH) D levels were significantly different in patients with different disease(p=0.044<0.05). Patients with nephropathy had lowest average serum 25(OH)D levels(39.89±23.66nmol/L) while hypertensive patients had highest average serum 25(OH)D levels(60.69±28.27nmol/L).Diabetes patients complicated with cardiovascular conditions had significantrly different 25(OH)D?TC?UA and Ca level compared with simple diabetes patients(P<0.05). In diabetes patients, 25(OH)D levels decrease along with the disease course. Moreover, 25(OH)D levels was negatively correlated to age?FIB?TC?and UA, positively correlated to D-dimer?HDL-C, and significantly correlated with FIB and TC(P<0.01). Multi-factor Logistic regression analysis, which took incidence of cardiovascular disease as the dependent variable, and 25(OH)D level together with oother cardiovascular risk factor as independent variable, showed that the cardiovascular risk was 1.17 times higher in patients with 25(OH)D deficiency(OR 1.17,P=0.035<0.05).CONCLUSION1. It is the first vitamin D dificiency investigation for in-patients over 60 yrs in Qingdao. Our results revealed that vitamin D deficiency occurred in 88.41% hospitalized patients, especially in man(88.75%) and older in-patients(89.19%).2. In patients with type 2 diabetes mellitus(>60 yrs), serum vitamin D levels was significantly correlated with cardiovascular risk factors such as age, FIB, TC, UA, D-dimer, HDL-C.3.Vitamin D deficiency is an independent risk factors for cardiovascular disease in patients with type 2 diabetes mellitus patients(>60 yrs).