The Clinical Research Of Pulmonary Function And Respiratory Muscle Function In 120 Cases Of Patients With Amyotrophic Lateral Sclerosis

ObjectiveTo research the characteristics of generally, pulmonary function and respiratory muscle function in patients with amyotrophic lateral sclerosis through the retrospective study method.MethodsWe put the standard of 120 cases of ALS patients as a research object, then collecting relevant data, analyze the general situation, pulmonary function and respiratory muscle function in patients with amyotrophic lateral sclerosis using statistical software.120 cases of ALS patients according to clinical onset methods can be divided into bulbar onset group (33 cases) and limb onset group (87 cases), to compare the pulmonary function and respiratory muscle function in the two groups.120 cases of ALS patients according to the course can be divided into a short course of disease group (12 months or less, n= 61) with the long course of disease group (>12 months, n= 59 cases), to compare the pulmonary function and respiratory muscle function in the two groups.ResultsThe average age of 120 cases of ALS patients is 54.36±12.12 years, onset age is 27 years old to 78 years old, the average course is 18 months. The male patients have 78 cases and the female patients have 78 cases. The number of men is more than women’s, the ratio of patients is 1.86:1. The bulbar onset patients accounted for twenty-seven point five percent and the limb onset patients accounted for seventy-two point five percent.48.33% ALS patients have normal pulmonary function,51.67% ALS patients have abnormal pulmonary function, VC is decreased, the difference has statistical significance (P<0.05), PEF、MVV、MIP、MEP is decreased, the difference has significant statistical significance (P<0.01).The ventilation dysfunction of 120 cases of ALS patients suggest that restrictive ventilatory dysfunction in 54 cases (45.00%),6 cases of mixed ventilation dysfunction (5%), obstructive ventilation dysfunction in 2 cases (1.67%). In other words, the patients of restrictive ventilatory dysfunction are 87.10% in the event of ventilation disorder patients.The bulbar onset and limb onset group of PEF, MVV is, MIP, MEP differences are significant statistical significance (P<0.01). The difference of MVV is statistically significant between short course of disease group and the long course of disease group (P<0.05), the difference of FVC, FEV1 has significant statistical significance (P<0.01).ConclusionIn the study,51.67% of abnormal lung function in patients with ALS (may prompt for duration 18 months on average lung function damage in patients with less obvious or hidden), is given priority to with restrictive ventilatory dysfunction in patients with pulmonary dysfunction, bulbar of group of PEF, MVV is, MIP, MEP decline degree is obvious at the limb group, showed that the respiratory muscle function of bulbar of onset group damage is more serious than limb onset group. As the time extend, VC, MVV is, FVC, FEVt decline change evident (statistically significant), we put forward the selection of VC, MVV is, FVC, FEV1 judge ALS patients treated can be used as indicators of lung function.