The Study On Epigastric Fullness(Functional Dyspepsia) With Syndrome Of Spleen Deficiency And Qi Stagnation Treated By Strengthening Spleen And Regulating Qi And Its Effecacy And Mechanism

ObjectiveFor better understanding epigastric fullness (functional dyspepsia, FD) with syndrome of spleen deficiency and Qi stagnation, this study reviews advances in mechanism of functional dyspepsia and epigastric fullness in TCM. Due to absence of targeted study, this study is mainly on effecacy and mechanism of epigastric fullness (FD) with syndrome of spleen deficiency and Qi stagnation treated by strengthening spleen and regulating Qi, providing new ideas for studying mechanism of epigastric fullness(FD) with syndrome of spleen deficiency and Qi stagnation and developing new drugs.MethodsThis study reviewed advances in mechanism of functional dyspepsia and epigastric fullness in TCM. This is a double blind, randomised, placebo controlled trial.60 subjects with FD were randomly divided into treatment group(40 subjects) and placebo group(20 subjects), treated by strengthening spleen and regulating Qi granules and placebo respectively. After treatment, integral of TCM symptoms, integral of postprandial distress, proximal gastric emptying, serum 5-HT, MTL, ghrelin changing will be compared between treatment group and placebo group.20 healthy subjects were seleted, and proximal gastric emptying, serum 5-HT, MTL, ghrelin will be compared between healthy subjects and patients with epigastric fullness(FD).ResultsProximal gastric emptying rate 60min,90min,120min after meal, the half of gastric emptying time and serum ghrelin were significantly different between healthy subjects and patients with epigastric fullness (FD) (P<0.01 or P<0.05), but no significant differences were found in proximal gastric volume at maximal satiety, serum MTL, ghrelin (P>0.05). After treatment, integral of bloating, anorexia, belching, acid regurgitation, total TCM syptoms, postprandial distress and proximal gastric emptying rate(60min, 90min,120min after meal), the half of gastric emptying time, sperum MTL, ghrelin were improved, compared to placebo group (P<0.01 or P<0.05). However, integral of other syptoms like stomachache, heartburn and proximal gastric volume at maximal satiety, sperum 5-HT seens no significantly differences(P >0.05).ConclusionProximal gastric emptying rate, the half of gastric emptying time, sperum ghrelin were different between healthy subjects and patients with epigastric fullness (FD). Some syptoms, proximal gastric emptying rate, the half of gastric emptying time, sperum MTL, ghrelin can be improved after treatment by strengthening spleen and regulating Qi. Mechanism of epigastric fullness (FD) with syndrome of spleen deficiency and Qi stagnation and treatment by strengthening spleen and regulating Qi were related to proximal gastric emptying, sperum MTL and ghrelin.