The Study On Functional Dyspepsia With Syndrome Of Spleen Deficiency And Qi Stagnation Treated By Jianpi Liqi Granule

ObjectiveTo observe the clinical effect of Jianpi Liqi granule in the treatment of patients with spleen deficiency and qi stagnation of functional dyspepsia.Methods48 patients with functional dyspepsia who met the inclusion criteria from the outpatient or hospitalized Department of Guangdong Province Traditional Chinese Medical Hospital were recruited into this trial.This is a randomized,double-blinded,placebo-controlled design,and the patients were treated by Jianpi Liqi granule and placebo respectively.The results of treatment were compared before and after treatment.The main symptoms and minor symptoms of functional dyspepsia were scored at zeroth and fourth weeks after treatment.The scores of TCM symptoms and the degree of dyspepsia were calculated and observed.The collected data are unified with SPSS 19 for statistical analysis.Results1.Overall score comparison of major symptomsBefore and after treatment,compared with the same group,the total score of the main symptoms of the treatment group decreased significantly after treatment,and the difference between the two groups was statistically significant(P<0.05).In the control group,the total score of the main symptoms decreased after treatment,but the difference was not statistically significant(P>0.05).The difference between the two groups before and after treatment was statistically significant(P<0.05).2.Comparison of single score of main symptomsAfter 4 weeks of treatment,the symptom scores of gastric epigastric fullness,stomachache discomfort,early satiety and heart burning were significantly reduced in the treatment group than before the treatment,and the difference was comparable before and after the treatment(P<0.05或P<0.01).There was no significant difference in symptom scores before and after treatment in the control group(P>0.05).The difference between the two sets of integral difference was better in the treatment group than in the control group,such as stomach fullness,stomachache,early satiation,heartburn and so on(P<0.05 或P<0.01).3.Comparison of total score of TCM SyndromeAfter treatment,the difference of the scores in the treatment group was statistically significant(P<0.05),and there was no significant difference between the two groups in the control group(P>0.05).After the treatment,the difference of the two syndrome scores was statistically significant(P<0.01).4.Comparison of TCM syndrome scoreAfter 4 weeks of treatment,the symptom scores of gastric epigastric fullness,stomach pain discomfort,laziness,shortness of breath and fatigue were significantly lower than those before treatment,and the difference of integral difference before and after treatment was comparable(P<0.05 or P<0.01).But there was no significant difference in the scores of other symptoms before and after treatment(P>0.05).There was no significant difference in symptom scores before and after treatment in the control group(P>0.05).The difference between the two groups was better than the control group in the gastric epigastric swelling,stomach pain discomfort,laziness,shortness of breath,fatigue and so on.The difference was statistically significant(P<0.05 or P<0.01),but there was no significant difference in the scores of other symptoms(P>0.05).5.Comparison of the total effective rate of TCM SyndromeAfter 4 weeks of treatment,the total effective rate of the patients in the treatment group was 93.94%,and the total effective rate of the control group was 27.27%.The two groups were indicated by the rank sum test P<0.01,the difference was statistically significant.6.Integral comparison of FDQOL quality of life scale(1)Comparison of FDQOL quality of life before and after treatment in the treatment groupAfter 4 weeks after the treatment of Jianpi Liqi granule,the scores of the five dimensions of daily activity(DA),anxiety(AN),diet(DI),health sensation(HP)and pressure(IS)were significantly improved(P<0.05),while the three dimensions of disease control(CD),sleep(SL),and discomfort(DT)were changed.There was no statistical significance in good(P>0.05).(2)Comparison of FDQOL quality of life before and after treatment in the control groupIn the control group,after 4 weeks of placebo treatment,the patients’scores on the stress(IS)dimension were significantly improved(P<0.05),while the seven dimensions of daily activity(DA),anxiety(AN),diet(DI),health sensation(HP),disease control(CD),sleep(SL),and discomfort(DT)were improved.Study significance(P>0.05)③Comparison of FDQOL quality of life scores in two groups of patients after treatmentAfter 4 weeks of treatment,the scores of the four dimensions of daily activity(DA),anxiety(AN),diet(DI),and health sensation(HP)were improved more significantly than those in the control group(P<0.05),while the four dimensions of stress(IS),disease control(CD),sleep(SL),and discomfort(DT)were not statistically significant Meaning(P>0.05).7.An integral comparison of anxiety and depression scaleAfter 4 weeks of treatment,the anxiety score of the patients in the treatment group was lower than that before the treatment(P<0.05),but the.score of depression was not statistically significant(P>0.05),and there was no statistical significance(P>0.05)in the control group,and the depression score was also less significant(P>0.05);after 4 weeks of treatment,two There was statistically significant difference in the scores of anxiety scale between the two groups(P<0.05),and there was no significant difference in the scores of depression scale between the two groups(P>0.05).Conclusion1.Jianpi Liqi granule has a certain therapeutic effect on patients with spleen deficiency and stagnation of functional dyspepsia.It can improve the main symptom discomfort,such as stomach distention,stomachache,and early saturating heart.2.Jianpi Liqi granule is more effective than placebo in the treatment of FD patients,especially gastric distention,stomachache discomfort,laziness,shortness of breath,fatigue and so on.3.Jianpi Liqi granules can relieve the symptoms of anxiety in patients with functional dyspepsia with spleen deficiency and qi stagnation,and it is superior to the consolation unit.But in terms of depression,Jianpi Liqi granule has no obvious effect as compared with placebo.4.Jianpi Liqi granules can improve the five dimensions of patients’daily activity(DA),anxiety(AN),diet(DI),health sensation(HP)and stress(IS),and the four dimensions of the four dimensions of daily activity(DA),anxiety(AN),diet(DI),and healthy feeling(HP))are superior to placebo.But in improving pressure(IS),the effect is not superior to placebo.