| ObjectiveThrough the clinical observation, define the clinic effect of berberine combined with Cang-Fu-Dao-Tan decoction in treating obese women with Polycystic Ovary Syndrome, in order to provide a better method for treatment.MethodsThis study collected 46 obese women with Polycystic Ovary Syndrome, randomly divided into treatment group and control group with 23 patients in each group. The treatment group was treated with berberine combined with Cang-Fu-Dao-Tan decoction and the control group was treated only with Cang-Fu-Dao-Tan decoction. Both groups were treated for 3 months. Observed the improvement of Clinical symptoms, Traditional Chinese Medicine (TCM) syndromes, Body Mass Index (BMI), Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), Testosterone (T), Fasting plasma glucose (FPG), Fasting insulin (FINS), ISI, Total cholesterol (TCHO), Triglyceride (TG), High-density lipoprotein cholesterol (HDL-C) and Low-density lipoprotein cholesterol (LDL-C) in both groups before and after treatment.Results1. After treatment, the cases of irregular menstruation were significantly reduced in both groups (P<0.05), and the treatment group was superior to the control group while the difference between two groups was statistically significant(P<0.05). Before treatment, there were 12 infertility patients in the treatment group but 3 of them were pregnant during treatment. There were 10 infertility patients in the control group and 1 of them was pregnant during treatment. There were 2 hirsute patients,2 acne patients in the treatment group and 2 hirsute patients,3 acne patients in the control group before treatment, while all of them reduced to 1 score after treatment.2. After treatment, there were 0 cured cases,2 markedly effective cases, 14 effective cases,4 ineffective cases in the treatment group and the total effective rate was 80%. While there were 0 cured cases,1 markedly effective case,9 effective cases,9 ineffective cases in the control group after treatment and the total effective rate was 52.63%. The treatment group was superior to the control group and the difference between two groups was statistically significant (P<0.05).3. The levels of LH, LH/FSH were all obviously decreased in both groups after treatment(P<0.05), but there was no significant difference between the two groups(P>0.05). The level of FSH showed no significant effect before and after treatment in both groups or between the both groups after treatment(P >0.05). The level of T in the treatment group was obviously decreased after treatment (P<0.05), while it was not obviously decreased in the control group after treatment(P>0.05); There was significant difference between the two groups after treatment (P<0.05).4. The levels of BMI, FINS were all obviously decreased in both groups after treatment(P<0.05), while the treatment group was superior to the control group and the difference between two groups was statistically significant(P <0.05). The level of FPG showed no significant effect before and after treatment in both groups or between the both groups after treatment (P>0.05). The levels of ISI were obviously increased in both groups after treatment(P <0.05), while the treatment group was superior to the control group and the difference between two groups was statistically significant(P<0.05).5. The levels of TCHO, TG, LDL-C were all obviously decreased in both groups after treatment(P<0.05), while the treatment group was superior to the control group and the difference between two groups was statistically significant (P<0.05). The level of HDL-C in the treatment group was obviously increased after treatment (P<0.05), while it was not obviously increased in the control group after treatment (P>0.05); There was significant difference between the two groups after treatment (P<0.05).Conclusion1. Berberine combined with Cang-Fu-Dao-Tan decoction in the treatment of obese PCOS patients, can effectively improve the patients’ phlegm dampness syndrome, shorten the delayed menstrual cycle, lower body mass index. And the efficacy is significantly better than that in the group cured by Cang-Fu-Dao-Tan decoction.2. Berberine combined with Cang-Fu-Dao-Tan decoction in the=treatment of obese PCOS patients, can lower the level of FINS and higher the level of ISI in order to improve the insulin resistance. It also can lower the levels of TCHO, TG, LDL-C and higher the level of ISI in order to regulate the level of blood lipid. Besides, it can lower the levels of LH, LH/FSH, T in order to balance the reproductive endocrine disorder and promote the normal menstrual cramps. The efficacy is significantly better than that in the group cured by Cang-Fu-Dao-Tan decoction.3. Berberine combined with Cang-Fu-Dao-Tan decoction is an economical, safe and effective treatment for obese PCOS patients. |
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