| Objective:To observe the clinical effect of Cangfu phlegm excretion pills on polycystic ovary syndrome with kidney deficiency and phlegm dampness.According to the change rule of female menstrual cycle,traditional Chinese medicine tonifying kidney and invigorating spleen,promoting dampness and expelling phlegm,analyzing the clinical observation result and discussing its action mechanism,provide an effective treatment scheme for polycystic ovary syndrome of kidney deficiency and phlegm dampness type.Methods:A total of 60 patients with polycystic ovary syndrome(PCOS)with kidney deficiency and phlegm dampness were collected and randomly divided into two groups.30 cases in each group were treated by Yasmin(Drospirenone and Ethinylestradiol Tablets)in the treatment group(n=30).The clinical symptoms,body mass index(BMI),determination of BBT,hormone level,insulin(INS),blood sugar content and HOMA-IR index were observed before and after treatment.Results:1.There was no significant difference in age,course of disease,insulin resistance level,body mass index and serum hormone level between the two groups(P>0.05).There was no significant difference between the two groups in single symptoms and signs of TCM,(P>0.05)by statistical analysis.2.Comparison of the total syndromes between the two groups:the two groups were significantly improved before and after treatment by statistical analysis(P<0.01),indicating that there is statistical significance.The results showed that the treatment group was better than the control group by statistical analysis(P<0.01).3.Comparison of symptoms of TCM before and after treatment in two groups:compared with before and after treatment,all symptoms of TCM in treatment group were significantly improved(P<0.01).Compared with before treatment,the patients in the control group only had significant improvement in menstrual cycle,menstrual volume,obesity,sexual desire and limb distress(P<0.01 or P<0.05),but no significant improvement in other indexes(P>0.05).In the five symptoms of menstrual cycle,menstrual volume,obesity,sexual desire and limb distress.Compared with the control group,the symptoms of these five groups of patients in the treatment group were significantly improved after treatmen(P<0.01 or P<0.05).The results suggest that the treatment group can improve all symptoms,while the control group can only improve the menstrual cycle,menstrual volume,obesity,sexual desire and limb distress.In particular,menstrual cycle and limb symptoms were significantly better improved than the control group.4.Comparison of reproductive hormone levels between the two groups before and after treatment:there was no significant difference in the levels of reproductive hormones between the two groups before and after treatment(P>0.05).After two courses of treatment,the serum FSH,E2 levels in the treatment group were significantly higher than those in the control group.There was a significant difference between before treatment and before treatment(P<0.01).The content of serum LH,T was significantly lower than that before treatment(P<0.01).In the control group,the change of serum FSH level after treatment was significantly different from that before treatment(P<0.05),but the change of E2 content was not statistically significant,which was slightly lower than that before treatment.This is slightly different from current clinical research.The content of serum LH,T was significantly lower than that before treatment(P<0.05,P<0.05).PRL was related to stress,exercise,sleep,diet and so on in physiological state.The patients were excluded from hyperprolactinemia.There was no significant difference between the treatment group and the control group before and after treatment(P>0.05).There was no significant difference in FSH,LH,T,PRL content between the two groups after treatment(P<0.05).5.Comparison of body mass index between the two groups before and after treatment:there was no significant difference in the body mass index between the two groups(P>0.05).After two courses of treatment,the body mass index of the patients in the control group was significantly lower than that in the control group.There was significant difference between before treatment and before treatment(P<0.01).There was no significant difference between the two groups after treatment(P<0.05).6.Comparison of insulin resistance between the two groups before and after treatment:there was no significant difference in insulin resistance between the two groups before and after treatment(P>0.05).After two courses of treatment,the level of insulin resistance in the control group was significantly lower than that in the control group.There was no significant difference between the two groups after treatment(P<0.01),but the results before and after treatment indicated that the curative effect of the treatment group was better than that of the control group(P<0.05).7.Comparison of BBT between the two groups before and after treatment:after two observation courses of treatment,the recovery rate of BBT in the two groups was 83.33%and 73.33%,respectively.It can be seen that both the treatment group and the control group can make BBT return to normal obviously.There was no significant difference between the two groups(P>0.05),but the curative effect of the treatment group was higher than that of the control group from the point of view of normal rate.8.Comparison of ovulation rate and clinical efficacy between the two groups:the ovulation rate in the treatment group was significantly higher than that in the control group,and there was no significant difference between the two groups(P<0.05).In the treatment group,26 cases were cured,2 cases were excellently effective,1 case was effective,1 case was ineffective,the cure rate was 86.67%,the total effective rate was 96.67%and the ineffective rate was 3.33%.In the control group,22 cases were cured,3 cases were excellently effective,and 1 case was effective,4 cases was ineffective,the cure rate was 73.33%,the total effective rate was 86.67%and the ineffective rate was 13.33%.There was no significant difference between the two groups(P<0.05).Conclusion:1.On the basis of western medicine,the addition of Cangfu phlegm excretion pills can improve the endocrine and insulin resistance of PCOS patients with phlegm dampness type,and improve the symptoms of the patients at the same time.2.Cangfu phlegm excretion pills could improve the metabolic disorder of serum follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),testosterone(T),and insulin(INS)in patients with PCOS and IR.3.On the basis of western medicine,the addition of Cangfu phlegm excretion pills can obviously improve the ovulation rate of infertile patients,which is worth popularizing in clinical treatment of infertility. |
PDF Full Text Request