| Objective:This study was designed to evaluate the function of transposed ovary after postoperative chemoradiotherapy(CRT) and its affecting factors in young women with cervical cancer.Methods:Clinical data of the 72 patients underwent ovarian transposition (OT) during radical hysterectomy(RH) treated in Department of Gynecologic Oncology,Fourth Affiliated Hospital of Guangxi Medical University from July 2009 to July 2014, were retrospectively analyzed.Ovarian function was evaluated by the questionnaire of climacteric Symptoms and Serum levels of follicle-stimulating hormone (FSH). Among 72 patients who underwent OT,46 patients underwent RH with OT and CRT were divided into research group.21 patients underwent RH with bilateral ovaries removed and CRT were included in control group.the perimenopausal symptoms and serum sex hormone levels were compared to explore the function of transposed ovary after CRT. Chi-square test or Fisher’s exact test was used to analyze Single factor affecting the function of transposed ovary.Finally, a Logistic Regression was used for multivariate analysis.Results:Ovarian retention was observed in 10 out of 46 cases after CRT in research group.Within one year after finishing all treatment the climacteric symptoms of patients in research group were significantly lower than in the control group. The ovarian function in research group was significantly better than in the control group(P<0.05).Single factor analysis showed CRT may be independent factor Influencing the function of transposed ovary(P<0.05).The multivariate analysis revealed that the age of patients and CRT were independent factors which influenced the function of transposed ovary(P<0.05). Conclusions:Ovarian transposition can partially reserve ovarian function after CRT and improve the quality of life after radiotherapy; the age of patients and CRT were independent risk factors which influenced the function of transposed ovary. |
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