Prenatal Diagnosis And Pregnancy Outcome Analysis Of Prenatal Fetal Ventriculomegaly

OBJECTIVE:To review the intrauterine diagnosis of chromosomal karyotypes,perinatal outcomes and neurological development of fetus with varying levels of lateral ventriculomegaly through ultrasonography and to put forward the actual clinical recommendations for eugenics and genetic counseling.METHOD:In our hospital’s prenatal and genetic disease diagnosis center,from Jan.2011 till Dec.2013, a retrospective research was performed on 107 singleton pregnancies,where the fetus’lateral ventriculomegaly(≥10mm) were confirmed by ultrasound examination and data collected from amniotic fluid and karyotyping of blood of umbilical vein.According to the level of the dilated lateral ventricles,107 cases were divided into mild group(10-12mm), moderate group (12.1-14.9mm) and severe group (≥15mm). According to complication of the ultrasonographic anomalies, the groups were divided into isolated lateral ventriculomegaly group and non-isolated lateral ventriculomegaly group.A follow up was done on the chromosomal karyotype, pregnancy outcome and prenatal diagnosis of lateral ventriculomegaly group.A comparison and analysis was done;in our prenatal diagnosis department,between the lateral ventriculomegaly group and control group (non ventriculomegaly group) of 50 cases of singleton pregnancy without any lateral ventriculomegaly,Mediterranean anemia, missed gestateonal serological screening or elderly pregnancy.RESULT:In 107 cases of patients with lateral ventriculomegaly,there were 47 cases of mild group,34 cases of moderate group,26 cases of severe group,50 cases of Isolated lateral ventriculomegaly,non-isolated 57 cases.44.7% of non-isolated ventriculomegaly cases involves with CNS abnormalities. The intrauterine diagnosis of chromosomal abnormality rate was 9.35%(10/107) in lateral ventriculomegaly group where no abnormalities were found in control group.On the comparison with the control group, the difference in the chromosomal abnormalities in moderate and severe lateral ventriculomegaly gr-oup was statistically significant (P< 0.05), where as the mild group does not increase the risk of chromosome abnormalities (P>0.05). Severe lateral ventriculomegaly leads to poor prognosis of termination of multiple pregnancy-es. Excluding abnormal chromosomal karyotype, the outcome of isolated later-al ventriculomegaly group of pregnancy are better than non isolated lateral ventricle group. During the comparison of the isolated lateral ventriculomegaly group of neonatal birth and development with the control group,the difference was not statistically significant (P>0.05).Similarly,when the non-isolated lateral ventricle group’s rate of fetal distress, the incidence of nervous system’s abnormalities rate was compared with the control group, the difference was statistically significant (P<0.05).CONCLUSION:Fetal lateral ventriculomegaly was significantly associated with fetal chromosomal karyotypic abnormalities and congenital abnormalities. After the exclusion of chromosomal abnormalities, the prognosis of fetus with non-isolated lateral ventriculomegaly was significantly lower than that of the lateral ventriculomegaly of normal neonates. For the lateral ventriculomegaly cases,during pregnancy, maternal fetal monitoring should be focused, especially for the non-isolated lateral ventriculomegaly of the fetus after birth to monitor the development of the nervous system, in order to improve the quality of the population.