Sodium Salicylate Reversibly Suppresses Gaba-Induced Currents Of Spiral Ganglion Neurons In Rat Cochlea

Objective:To study the effect of sodium salicylate(SS) on the function of GABAa receptors in spiral ganglion neurons(SGNs).Method:GABAa receptor currents were recorded using whole-cell patch clamp technique in acute isolated SGNs. The effects of SS were characterized.Results:The currents evoked by GABA in SGNs were blocked by 10μM bicuculline.No detectable currents were recorded by using SS in 0.5mM,0.1mM and 5mM separately.But suppressions of GABA-induced currents were observed by administrating GABA(100μM and 500μM) combining with SS.Conclusion:GABAa receptors currents could be recorded in rat cochlea SGNs.The results demonstrate that SS reversibly attenuates the GABAa receptors response of SGNs.The effects were reversible and dose-dependent on GABA and SS.