Inhibition On Voltage-gated Potassium Channels In Rat Spiral Ganglion Neurons By Salicylate

Objective:To study the effects of sodium salicylate on the function of voltage-gated potassium channels in the spiral ganglion neurons.Methods:voltage-gated potassium channel whole-cell currents were recorded using patch clamp in acute isolated SGNsResults:The voltage-gated potassium channel (K(V)) current peak was inhibited by sodium salicylate in a dose-dependent manner, even the low concentrations of10μ M. However, its impact on steady-state activation curve of The voltage-gated potassium channel current peak was not significant. At a low concentration of10μ M, sodium salicylate did not shift the voltage-gated potassium channel current steady-state or its activation curves. But at the high concentration (>100μM), sodium salicylate evoked rapid reduction of voltage-gated potassium channel current steady-state.Conclusion:The sodium salicylate inhibits both voltage-gated potassium channel current peak and voltage-gated potassium channel current steady-state in SGNs in a dose-dependent manner, its impact on steady-state activation curve of The voltage-gated potassium channel current peak was not significant.