Diagnostic Value Of Serum Cystatin C For Renal Function Impairment In Neonatal Asphyxia

Objective: By detecting the serum Cystatin C(Cys C) levels in normal newborn and asphyxia neonates, and to explore the change of Cys C in asphyxia newborn, analysis of the correlation among the indicators when renal damaged, We can evaluate the practical evaluation of Cys C in asphyxia newborn babies by early diagnosis, estimate disease condition and analysis prognostic,in order to provide the theoretical basis in early diagnosis and treatment of asphyxia newborn when renal damaged.Method:According to the neonatal asphyxia diagnosis and dividing standard from the fourth edition of "the practical neonatology”, newborn asphyxia were divided into mild asphyxia group(50 cases), severe asphyxia group(50 cases);Selected 20 cases of healthy full-term babies in the same period as the control group. All of the observed asphyxia group children after birth 1, 3, 7 days, the control group with 2 ~ 3 days after birth, were respectively taken 2 ml peripheral venous blood.With the method of enzyme linked immunosorbent(ELISA) to detect serum Cystatin C(SCys C), serum creatinine(SCr), blood urea nitrogen(blood urea nitrogen, BUN) and blood beta 2- micro globulin level.According to Schwartz, the formula to calculate the estimated glomerular filtration rate(estimate glomerular filtration rate, e GFR),Comparison the change of above indicators between groups of different time, with e GFR as an evaluation standard of kidney damage, to observe the diagnostic value of serum Cys C on renal impairment.The data statistical processing by SPSS17.0 software.Results:1 The level of Cys C, beta 2- MG, SCr and BUN is obviously higher in asphyxia group than that in control group, severe asphyxia group is more significant higher degree than that in the mild asphyxia group(P < 0.05);The level of the Scr, BUN, beta 2- MG and serum Cys C gradually reduce in asphyxia group after treatment, The indicators were higher in mild asphyxia group one day after the birth than the control group, the difference had obvious statistical significance(P < 0.05), but had no statistical difference between the control group three and seven days after birth, Each indexes in severe asphyxia group at one day and three day were higher than in the control group and mild asphyxia group, the difference had obvious statistical significance(P < 0.05), at seven day between above groups had no statistical difference.2 The beta2- MG and serum Cys C level between Scr and BUN present obvious positive correlation(P < 0.05), while and e GFR appear obvious negative correlation(P < 0.05)3 With e GFR as an evaluation standard of renal impairment, 51 cases of neonatal asphyxia group happen renal impairment, compared with the level of Cys C, beta 2- MG, SCr, BUN,one days after admission, we found that serum Cys C has the highest sensitivity and specific degree, through the statistical analysis showed that the sensitivity is higher than BUN, specific degrees higher than that of SCr and BUN, differences were significant statistical significance(P < 0.05), there was no significant difference compared with beta 2- MG statistical significance(P > 0.05)Conclusion: Serum Cys C level can be used as early detection indicators of asphyxia newborn glomerular filtration function, and have better sensitivity and specificity for early diagnosis of renal damage, providing more reliable indicators for clinical monitoring of renal function.