Study On The Correlation Between The TCM Syndrome Factor Of Chronic Atrophic Gastritis And Gastric Mucosa Pathological Changes

Objective:To discuss the chronic atrophic gastritis (the CAG) syndrome factor distribution cha racteristics and its correlation with gastric mucosa pathological changes,to provide new ideas for clinical syndrome differentiation of traditional Chinese meidicine,for gastric mucosa cancer to provide the cheory basis for early prevention and intervention.Methods:Adopt the method of questionnaire survey,collect specific diagnosis the CAG by the electronic gastroscopy and pathological biopsy,with 90 patients with clinical symptom s,and included in the standard,collect the patient’s symptom information,through the s oftware system of statistical distribution of the CAG syndrome factor,analyzed the cor relation between the CAG syndrome factor and gastric mucosa pathological changes.Results:1.The distribution of different CAG in different age stages,the most to middle-aged (45～59 years old),accounts for about 55.6%.2.The CAG syndrome factor distribution features:the syndrome elements of disease 1 ocation involved in the stomach,spleen,kidney,liver,bravery,the most common in the sto mach,compared with the other disease syndrome factor has the difference(P<0.05).The disease syndrome factor related to qi deficiency and qi stagnation, wet,and Yang defic iency, phlegm,heat,food retention,blood stasis,Yin deficiency, blood deficiency,cold,hand. Stagnation of qi is the most common,and other symptom factors of disease nature co mpared with differenc(P<0.05).3.Syndrome factor relationship with the degree of gastric mucosa pathological chang es:(1)there is a positive correlation between the syndrome elements of disease location of stomach,spleen,liver and CAG gastric mucosal inflammatory changes(P<0.01).That is the disease syndrome element of the stomach,spleen,liver score more higher,the hi gher the degree of chronic inflammation.(2)There is a positive correlation between dis ease syndrome factor of qi stagnation,wet,qi deficiency,Yang deficiency, phlegm,heat,foo d retention,blood stasis,Yin deficiency,blood deficiency and CAG gastric mucosal infla mmation(P<0.05). That is the disease of the syndrome factor score more higher,the hi gher the degree of chronic inflammation.4.Syndrome factor’s influence on the CAG precancerous lesions occur:(1)The syndr ome elements of disease location for the risk of gastric intestinal metaplasia factors(O R value equal to 3.014>1).The spleen is the protective factors of intestinal metaplasia (OR value is equal to 0.549<1).The spleen is the protective factors of intraepithelial n eoplasia(OR value equals 0.433<1).Liver is the danger of intraepithelial neoplasia (OR value is equal to 3.149>1).(2)Qi deficiency,wet,heat,blood stasis were risk factors of intestinal metaplasia(OR value is equal to 2.617,2.035,2.418,2.140 respectively>1). And qi stagnation,blood deficiency as a risk factor for intraepithelial neoplasia(OR value i s equal to 2.603,18.676>1)respectively.Conclusion:1.The stomach,spleen and liver for the CAG main disease,from the stomach,spleen and liver differentiation with theoretical basis.The empirical is common in qi stagnatio n,dampness,phlegm,heat,blood stasis and dyspepsia.Deficiency syndrome is common in qi deficiency Yang deficiency and Yin deficiency.2.The CAG degree of chronic inflammation is closely related to the stomach,spleen and relieving liver,and wet,qi deficiency,Yang deficiency,phlegm,heat,food retention,bl ood stasis,Yin deficiency,blood deficiency are closely related.3.Qi deficiency,dampness,heat,blood stasis and stomach is the CAG intestinal metapl asia of risk factors.Qi stagnation,blood deficiency and liver is the CAG intraepithelial neplasia of risk factors.Disease of spleen are protective factors of CAG with intestinal metaplasia or intraepithelial neoplasia occurred,and so on that clinical treatment of C AG should pay attention to spleen.