Analysis Of Environmental Risk Factors Of Childhood Leukemia

Objective:At present, the etiology and pathogenesis of childhood leukemia is not clear and many scholars believe that the occurrence of leukemia is the result of interaction of environmental and genetic factors. To explore the risk factors of childhood leukemia, thus provides the theoretical basis for the prevention of childhood leukemia. Methods:According to the design of a case-control study, 168 cases of CL under 16 years old were recruited from three hospitals in Henan from April 2014 to May 2014, as well as 168 children in department of respiration, traditional Chinese medicine or rehabilitation of the same hospitals were recruited as controls, which were excluded suffering with blood system diseases or other tumors. Information was obtained by our designed questionnaire. The questionnaire include four dimensions, they are general social demographic features, children related risk factors, mother and father’s related risk factors. Trained and standardized personnel conducted an face-to-face interview with both parents of the indexed child. According to the single factors analysis, the significant factors were analyzed with the multi-factors unconditional logistic regression analysis. Results:In the single factor analysis, residence, birth weight, methods of delivery, family history of lymphatic or hematopoietic system disease, residential exposure to ELF-EMF, the pollution of the environment around residence, X-ray/CT exposure history, exposure to harmful or toxic chemicals, parental education, history of abortion, maternal exposure to harmful or toxic chemicals 6 months before pregnancy and/or during pregnancy, parental exposure to X-ray/CT and parental exposure to harmful or toxic chemicals before pregnancy were statistical significance(P<0.05). While in the multi-factors Logistic regression analysis, there were 7 out of 14 indexes with significance(P<0.05), which of those are birth weight, family history of lymphatic or hematopoietic system disease, residential exposure to ELF-EMF, the pollution of the environment around residence, exposure to harmful or toxic chemicals before diagnosis, maternal exposure to harmful or toxic chemicals 6 months before pregnancy and/or during pregnancy, parental exposure to harmful or toxic chemicals before pregnancy. ConclusionIt is shown that birth weight, family history of lymphatic or hematopoietic system disease, residential exposure to ELF-EMF, the pollution of the environment around residence, exposure to harmful or toxic chemicals before diagnosis, maternal exposure to harmful or toxic chemicals 6 months before pregnancy and/or during pregnancy, parental exposure to harmful or toxic chemicals before pregnancy may increase the risk of the childhood acute leukemia. We should reduce the exposure of these risk environmental factors by artificial control and decrease the incidence and mortality of children leukemia.