Indoor Pesticides Exposure And Risk Of Childhood Acute Leukemia

Objective1. Part Ⅰ To investigate the Indoor environment risk factors of childhood acute leukemia, and to provide evidence for the primary prevention.2. PartⅡ To assess the relationship between exposure to pyrethroid pesticides and childhood acute leukemia.Methods1. Part Ⅰ An exploratory case-control study was conducted. From January2011to August2012, a total of31children aged0to14years with newly diagnosed acute leukemia, among whom28were diagnosed with acute lymphocytic leukemia and the other3with acute non-lymphocytic leukemia. The controls were selected in the same community where cases lived in accordance with the ratio of1:2, and matched with the cases by gender and age (±0.5years old).Face to face interviews with parents of cases and controls children were collected for general data and potential environmental risk factors, Univariate and multivariate conditional logistic regression analysis was conducted.2. Part II Urinary metabolites of pyrethroid pesticides were detected in urine samples of31cases and62controls by using gas chromatography with mass spectrometry. Creatinine concentrations were used to adjust the concentration of pyrethroid pesticides. Paired samples t test and multivariate conditional logistic regression analysis was conducted. Results1. Part I Indoor environmental risk factors of childhood acute leukemia.Using cockroach in family during children0-3years old was associated with an increased risk of childhood acute leukemia (AL).Higher education level might be associated with a lower risk of childhood AL (greater than college:OR=0.025,95%CI:0.002-0.301) compared with a lower educational level (lower than high school).2. PartⅡ The relationship between exposure to pyrethroid pesticide and childhood acute leukemia.The creatinine-adjusted geometric means of Cis-DCCA and Trans-DCCA in cases(0.38and0.82μg/g, respectively) were significantly higher than those in controls(0.17and0.47μg/g, respectively) except for3-PBA(cases:0.61μg/g; controls:0.68μg/g). After multi-logistic regression analysis, we found that exposure of pyrethroid pesticide exposures might be risk factors for childhood acute leukemia.Conclusions1. Part I Indoor environment risk factors of childhood acute leukemiaUsing cockroach during0-3years old in family may be associated with an increased risk of childhood acute leukemia, and paternal higher educational level might be a protective factor for childhood acute leukemia.2. Part II Exposure to pyrethroid pesticide might be associated with the risk of childhood acute leukemia.