Study On The Clinical Of "Smooth Liver" And "Calm Liver" On Hypertension Induced Liver-Yang Hyperactivity In Syndrome Young And Middle-aged Patients

ObjectiveStudy the the clinical efficacy of "smooth liver" and "calm liver" on hypertension induced liver-yang hyperactivity syndrome young and middle-aged patients, and further explore the mechanism of the treatments in order to lay the foundation for developing a kind of traditional Chinese medicine used to treat hypertension induced liver-yang hyperactivity syndrome among the young and the middle-aged.MethodsFrom the Second Hospital of Guangdong Province,105 cases of young and middle-aged outpatients and inpatients of cardiovascular, who have contracted hypertension induced liver-yang hyperactivity, have been collected from October 2013 to October 2014. They were randomly divided into three groups: the treatment group has 35 cases and taken Pinggan Rougan square particle, once a day; the control group has 35 cases and taken 80mg telmisartan, once a day; the Chinese and Western medical group has 35 cases and taken Pinggan Rougan square particles and telmisartan. The three groups all took a course of 12 weeks. Observe the clinical symptoms and syndromes of the three groups before and after treatment symptom scores, and measure their blood pressure, plasma renin, and angiotensin Ⅱ level.ResultsSymptom scores:before the treatment, there is no significant change in the symptom scores of three groups (P>0.05), and after the treatment, there is a significant decline (P<0.05), which has a statistical significance. After the treatment, compared with the control group, symptom score decreased significantly in the treatment group (P<0.05), which has a statistically significance;there is no significant difference between the treatment group and the Western medicine group (P>0.05); and there is a significant difference between the control group and the Western medicine group (P<0.05).Aspects of blood pressure effect:in systolic aspect, after 12 weeks of treatment, the systolic blood pressure of the three groups is decreased significantly after treatment (P< 0.05), which has a statistical significance. Compared with the treatment group, systolic blood pressure levels is significantly decreased in the control group (P<0.05), which is statistically significant;compared with the treatment group, systolic blood pressure in the Chinese and Western medicine group is significantly decreased (P<0.05), which isstatistically significant; there is no significant change in the systolic blood pressure for the Chinese and Western medicine group compared with the control group (P>0.05), which is not statistically significant. DBP aspect, after 12 weeks of treatment, it is significantly decreased in stretching pressure levels for the three groups than before (P <0.05), which has a statistical significance.compared with the control group, the diastolic blood pressure levelshas significantly decreased in the treatment group (P<0.05).which is statistically significant;compared with the treatment group, the diastolic blood pressure was significantly decreased in the Chinese and Western group (P<0.05), which is statistically significant;and, compared with the control group, the diastolic blood pressure levels was significantly decreased in the Chinese and Western group (P<0.05), which is a statistical significance.Aspects of plasma renin and angiotensin Ⅱ:before the treatment, there is no significant differences in the three groups (P>0.05). After the treatment, the plasma renin and angiotensin II levels are decreased significantly in the three groups than before (P<0.05), which is statistically significant; after treatment, there is no significant difference between the treatment group and the control group (P>0.05); compared with treatment group and control group, there is a significant decline in the Chinese and Western group (P＜0.05), which has a statistical significance.ConelusionThe research found that "smooth liver" and "calm liver" on hypertension induced liver-yang hyperactivity syndrome can significantly improve the clinical symptoms, and combining with Western medicine, can better regulate blood pressure, lower serum levels of renin and angiotensin Ⅱ. And they are clinically effective for hypertension induced liver-yang hyperactivity syndrome young and middle-aged patients and worth clinical using.