To Study The Distinct Phenotypes Of Distribution Regularity Of TCM Syndrormes Of COPD

Objective:Through collecting and arraging the clinical data of COPD patients, we can discuss the law of diffrent TCM syndromes distributing in COPD phenotypes. it will be the foundation of the conbined treatment oftraditional Chinese medicine and western medicine of COPD patients individually.Methods:Using retrospective study and arraging the clinical data including the age, sex, symptoms, smoking index, BMI, mMRC, the rate of AE, CT report, TCM syndromes, medical history, the tongue and pulse of all COPD patients of the department of the first affiliated hospital of Guangzhou university of Chinese medition during Jan 2010 to Dec 2014. Accoding to TCM theory, COPD patients are divided into 6 kinds of syndrome types:phlegm yu lung heat, phlegm turbidity resistance lung, phlegm and blood stasis resistance lung, lung and kidney deficiency, Yang deficiency water, and according to the Spanish guide and The Czech republic guide of 2013, we can divided those patients into 5 different kind of phenotypics:Frequent exacerbations of emphysema phenotype, Frequent phenotype, COPD exacerbations of chronic bronchitis with bronchiectasis phenotype, a cosine, Frequent exacerbations phenotype. Through statistical analysis,we would like to discover the law of diffrent TCM syndromes distributing in COPD phenotypes.Results:Included in the study of 639 patients, phenotype and TCM syndrome types have significant correlation(X=252.344, P=0.000). Different phenotypes of TCM syndrome type distribution is as follows:belonging to COPD combined with 90 cases in the phenotype of bronchiectasis, with phlegm and blood stasis resistance is close to the lung, the distance is 0.813, and the frequency for a maximum of phlegm heat yu lung occupies 45 cases, and no outside cold drinks and Yang deficiency water within it. Phenotype of frequent exacerbations of chronic bronchitis, or emphysema, a total of 198 cases with sputum heat yu lung relationship is relatively close, the correlation distance is 0.446, the largest distribution frequency for phlegm heat yu lung, a total of 63 cases. Belongs to frequent exacerbations of chronic bronchitis phenotype, a total of 117 cases with phlegm turbidity resistance is close to the lungs, correlation distance was 0.287, and the largest frequency distribution for phlegm heat yu lung has 54 cases, followed by the lungs and phlegm turbidity resistance. A cosine phenotype, a total of 63 cases, it is close to outside in the cold drink, and the distance is 0.567, the largest distribution for cold drinks,27 cases of possession. Belong to the frequent phenotype, a total of 171 cases of acute exacerbation of emphysema, its close to lung and kidney empty, and related to the distance of 0.134, up to type for lung and kidney deficiency of TCM.Conclusions:COPD phenotype and TCM syndrome types are significantly associated. Including COPD combined phenotype closely associated with phlegm and blood stasis resistance lung bronchiectasis, and outside in the cold drinks and Yang deficiency type water flooding this two certificate is hardly appeared in COPD combined expansion phenotypic team. The frequent exacerbations of chronic bronchitis or emphysema phenotype closely associated with phlegm heat yu lung. Frequent exacerbations of chronic bronchitis phenotype closely associated with lung phlegm turbidity resistance. A cosine phenotype closely associated with cold drink inside outside. Frequent exacerbations of emphysema phenotype closely associated with lung kidney deficiency.