The Expression And Clinical Significance Of TSPAN-1 And VEGF-C In Squamous Cervical Cancer

Objective:To study the expression of TSPAN-1 and VEGF-C in the normal cervical epithelium(NCE), cervical intraepithelial neoplasia(CIN) and squamous carcinomas of cervix(SCC), and to investigate the relationship of TSPAN-1 and VEGF-C in the occurrence and development of squamous carcinomas of cervix. Methods:Immunohistochemistry SP was employed to detect the expression of TSPAN-1 and VEGF-C in45 cases of SCC,30cases of high level CIN and 15 cases of NCE. This study was to explore the relationships between the two kinds of protein expression and the clinical pathological parameters of SCC.% χ2 test or Fisher’s exact test was used to identify the difference among groups for frequency data; spearman correlation was conducted for correlation test.Results:1. In The process of normal cervix to the cervical intra-epithelial neoplasia To cervical squamous cancer the expression of TSPAN-1 inease gradually (P<0.05).2.The positive expression rates of TSPAN-1 were not associated with clinical pathological index of SCC such as age, FIGO stages(P>0.05),historical differentiation, but associated with the depth of tumor invasion and lymph node metastasis(P<0.05).3. In The process of normal cervix to the cervical intra-epithelial neoplasia To cervical squamous cancer the expression of VEGF-C inease gradually (P<0.05).4.The positive expression rates of VEGF-C in SCC were not associated with clinical pathological index of SCC such as age, FIGO stages(P>0.05),but associated with historical differentiation, the depth of tumor invasion and lymph node metastasis(P<0.05).5. The expression level of TSPAN-1 and VEGF-C in cervical squamous cancer Were positively correlated (r=0.851, P<0.05) 。Conclusion:l.The expression of TSPAN-1 and VEGF-C in the cervical tissure of different research object:In the process of normal cervix to the cervical intra-epithelial neoplasia to cervical squamous cancer the expression of TSPAN-1 and VEGF-C incease gradually (P<0.05), but the positive expression level of TSPAN-1 and VEGF-C in cervical squamous Cancer have non-significant higher than it in the cervical intra-epithelial neoplasia(P>0.05).2. There was no correlation between the expressions of TSPAN-1, VEGF-C and the pathoclinical parameters, including the age, FIGO stages(P>0.05),but associated with the depth of tumor invasion and lymph node metastasis in SCC(P<0.05).3. The expression of TSPAN-1 was correlated with that of VEGF-C in SCC.