74 Cases Systemic Lupus Erythemat- Osus With Clinical Analysis Of Herpes Zoster

Objective:To summarize the clinical characteristics of systemic lupus erythematosus patients with herpes zoster and its related risk factors.Methods:The clinical data of systemic lupus erythematosus patients with herpes zoster and pure systemic lupus erythematosus patients was analyzed Restropectiwely from January 2006 to September 2014 in the first attiliated hospital of GuangXi Medical University, to collect patients clinical data,laboratory examination results,basic treatment,etc. To summarize the clinical characteristics of systemic lupus erythematosus patients with herpes zoster and its related risk factors.Results:1、Nearly eight years,there are 132 cases of SLE with HZ patients,exclude other infection and severe basic diseases,there 74 cases. There are 17 cases from 10 to 18,40cases from 19 to 45,15 cases from 46 to 65,2 cases more than 66;there are 14 cases attacked in the spring,26 cases in the summer,17 cases in the autumn,17 cases in the winter. There are 5 cases are extensive,12 cases involving the cranial nerve,9 cases of cervical plexus and 40 cases of intercostals nerve,8 cases of sacral; 20 cases occurred in plateau,30 cases occurred in mind acticity,22 occurred inmoderate,2 cases occurred in heavy period.2.The most initial symptom are joint pain and facial erythema in the two groups patients.While,edema also is the most initial symptom in observation group.Compating the two groups,edema,the renal involvement, the number of organ involved and the SLE-DAI scores.The differences are statistically significant.3. Observation group compared with control group,CD4 percentage, serum albumin, C3、C4 and IgG、IgA、IgM level in observation group is lower than the control group,24 hours urinary protein is higher than the control group,the difference was statistically significant.4.Observation group compared with control group:the average dosage of glucocorticoid in 1 month,impact used glucocorticoid and CTX therapy,the kind of immune inhibtors used,CTX cumulants,MTX used are higher than the control group,the difference was statistically significant.5.The risk factor of SLE with HZ analysis shows:24 hours urinary protein,the kinds of of immune inhibtors used,impact used glucocorticoid and CTX therapy,CTX cumulants,MTX used,kidney damage,the number of organ damage and the SLE-DAI scores are the risk of infection HZ;IgG and serum albumin are the protecttion factors.While,impact used glucocorticoid, CTX cumulants,MTX used,IgG are the independent factors.In accordance with the OR value, its risk order from large to small is CTX cumulants,CTX cumulants,MTX used.6.To compared in observe group:the dosage of hormone and the hormone decrement are no effect of the HZ course. And SLE-DAI scores are no difference in the HZ infected before and in the course.In the course of HZ,the IgG、IgA、 IgM are lower than the before,the difference was statistically significant.Conclusion:1.The risk factors of SLE with HZ are 24 hours urinary protein,the kinds of of immune inhibtors used,impact used glucocorticoid and CTX therapy,CTX cumulants,MTX used,kidney damage,the number of organ damage and the SLE-DAI scores;the protest factors are IgG and serum albumin.2.In accordance with the OR value, its risk order from large to small is CTX cumulants,impact used glucocorticoid,MTX used.3.SLE with HZ infection had no effect to lupus acrivity.During the course of HZ,no need to reduce the hormone and immune inhibitors.