| Objective: Malignant tumor of digestive is one of the main causes of death, with its increasing incidence. Gastric is a common malignant tumor of digestive tract,whose morbidity and mortality is of the third place in malignant tumors.Meanwhile, incidence of type 2 diabetes mellitus is rising in China.It showed that,the number of diabetes in the world had reached to 246 million until 2007, this international figure will increase to 380 million by 2025,the Diabetes Federation is expected, and china will be one of the hardest-hit areas.Existing research shows that, there is correlation between diabetes and gastric cancer and diabetes may increase the risk of gastric cancer.For all this,it remains controversial,reporting about the effects of diabetes, such as blood glucose level, duration and hypoglycemic drugs,on the development and progression of gastric cancer is rare.In practice clinical, due to the lack of awareness of the relationship between diabetes and gastric cancer, specialists often have more focus only on their respective professional issues, rather than systematic comprehension on examination and treatment of diabetes patients, lacking of comprehensive treatment measure,which is not conducive to the prevention and treatment of diabetic patients with gastric cancer,there by making the treatment and the quality of life of these patients seriously harmed.So understanding the related factors of diabetes on the development and progression of gastric cancer and further mechanism has become an urgent work.Clinical information of 500 cases gastric cancer patients and 500 cases non-gastric cancer patients were recalled in this study,aimming to investigate the effect of type 2 diabetes on the development and progression of gastric cancer and the expression level of insulin like growth factorⅠ(IGF-Ⅰ),its receptor IGF-ⅠR, IGF-II and its receptor IGF-IIR, were tested for further mechanisms, offering a theoretical foundation for clinical prevention diagnosis and treatment.Methods:500 cases of gastric cancer patients and 500 cases of non-gastric cancer(confirmed by biopsy) patients as control group were collected randomly in the People’s Liberation Army 252 hospital between January 2012 to December 2014, the other serious systemic illness were excluded.Compare the incidence of diabetes and glycemic control of the two groups.40 samples of gastric cancer tissues(18 cases with diabetes mellitus,22 cases without) and 10 cases of normal gastric tissues were selected and changes of level of expression of IGF-Ⅰ,IGF-ⅠR,IGF-Ⅱand IGF-ⅡR in gastric carcinoma,paracancerous and normal gastric tissues were tested.Results:1 19% of the patients were with diabetes mellitus,which was higher than that for 11% in non-gastric cancer patients(P<0.01).2 58.9% of 95 cases of gastric cancer patients whose FBG(fasting bloodglucose)was more than 7.0mmol/L with diabetes was higher than 23.6% of diabetes patients whose FBG(fasting blood-glucose)was more than 7.0mmol/L without gastric cancer(P<0.01).3 The level of expression of IGF-Ⅰ,IGF-ⅠR,IGF-Ⅱand IGF-ⅡR in gastric carcinoma tissues were significantly higher than in paracancerous and normal gastric tissues(P<0.01).4 The level of expression of IGF-Ⅰ,IGF-ⅠR,IGF- Ⅱand IGF-ⅡR in complicated with diabetes mellitus tissues were significantly higher than in gastric carcinoma tissues(P<0.01).Conclusions: Diabetes mellitus accelerated the development of gastric cancer, hyperglycemia may increase the risk of gastric cancer with the mechanisms that development and progression of gastric cancer were related to the increase of expression of IGF-Ⅰ,IGF-ⅠR,IGF-Ⅱand IGF-ⅡR. |
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