| Objective: Observing the level of serum uric acid(UA)and Homocysteine(HCY)in patients with acute cerebral infarction,AS well AS the effect of berberine(BBR) on the two level of serum UA and the degree of neural function defect on those indexes above.To investigate the relationship between serum UA,HCY and the degree of neural function defect,HCY level and acute cerebral infarction and to study the effect and possible pathophysiologic mechanism of UA and HCY to the acute cerebral infarction.Methods : 57 healthy persons as normal-control group and 88 patients with cerebral infarction as case group coincident with the diagnosis of acute cerebral infarction.The two groups are composition comparable in age and gender. By contrast research method and treatment plan,the case group were randomly divided into the case-control group(51cases) and BBR group(37cases), two groups in age gender and severity of ill condition were comparable.Hitach autobiochemistry instrument was used to measure the level of UA( by Enzymatic determinatio, μmol/L), Homocystein( HCY)( by Determination of circulating enzymatic metho,μmol/L).The changes of above parameters were recorded before and after treatment,as well as assessed degree of neural function defect with the National Institute of Health stroke scale(NIHSS).The data Within 48 hours(before treatment) were marked as “1”and the data On the seventh day(after treatment) were marked as “2”, and “1 mius2” wasmarked as “D-value”.In this study, SPSS 20.0software was used for statistical analysis and the significance test of the bilateral level was less than 0.05(p<0.05).Results:1.The levels of serum UA 1 in case group(308.05±85.16)were significantly higher than that(283.21±53.19)in normal-control group,(p<0.01),the difference has statistically significance.The levels of UA 2 in case group(294.46±85.86)were higher than that in normal-control group,the difference has no statistically significance.The level of UA2 has statistically lower than UA1(p<0.01).The level of HCY before treatment( 17.61±10.14) was statistically higher than that and the level of after treatment was statistically higher( 17.12±9.42) than that in normal-control group(12.59±7.36),the level of HCY2 was statistically lower than HCY 1(p<0.05).2.The level of serum UA and UA 2 in case group has no significant corre lation with NIHSS1 and NIHSS 2(4.11±2.67,2.65±2.27).The level of serum UA1 in case group has significant negative correlation(r=-0.239,P<0.05)with NIHSS D value(1.49±1.97),the level of UA1 has approximate significant pos itive correlation with HCY1(r=0.230,p=0.061),while significant positive correl ation with HCY 2(r=0.387,p<0.05).The serum UA2 has significant positive c orrelation with the level of HCY2(r=0.257,p<0.05), but no significant correlat ion with HCY1.The UA D value has positive correlation with NIHSS1,NIHSS2,HCY1,HCY2,HCY D value,while negative correlation with NIHSS D value,but th ere were no significant correlation. The level of serum HCY D value has signifi cantly negative correlation with the level of UA2(r=-0.340,p<0.05),but no si gnificant negative correlation with NIHSS1 and NIHSS2 and no significant positi ve correlation with NIHSS D value.3. The NIHSS scores before treatment has no significantly difference in BBR group and case-control group.The NIHSS scores after treatment(3.08±2.56,2.05±1.67) were notable lower than before treatment( 4.18±2.57, 4.03±2.84) both in case-control group and BBR group(p<0.01,p<0.01), and the change in BBR group was more apparent. The NIHSS D value in BBR group(2.03±2.51)was significantly higher than that(1.1±1.38) in case-control group(p<0.05).4. The levels of serum UA2(308.11±99.05,279.77±99.05)were lower than UA1(322.62±74.05,286.66±74.05)both in case-control group and BBR group, but the UA D value in BBR group was more apparent and has statistically significance.The levels of HCY2( 17.78 ± 7.68) were higher than HCY1( 16.06 ± 11.78) in case-control,and there were no statistically significance difference,while the level of serum HCY2(16.06 ±11.78) was statistically significance lower than HCY1(18.85 ±13.93) in the BBR group.5.In the 37 cases of the berberine groups, there was constipation in 6 cases, and with the treatment of cathartic all of them got better,while there was 4 cases in 51case-control group patient.There were no other adverse reaction occurred.Conclusion:1.The level of serum UA and HCY were increased significantly in patients with acute cerebral infarction,and there is a significant positive correlation between them. 1.It promoted that UA might take part in the pathophysiologic mechanism of the acute cerebral infarction.2.The level of UA could reflect the degree of recovery of cerebral infarction,the high level of disease improvement is not obvious.3.BBR could decrease the level of serum UA,HCY and the degree of neural function defect.It indicated that BBR might improve the prognosis of acute cerebral infarction.4.Berberine might be a safety and effective drug of acute cerebral infarction. |
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