Clinical Application Of Three Kinds Of Biomarker On Diagnosis Of Early Infectious Fever In The Intensive Care Cancer Patients

Objective:To investigate the clinical significance of monitoring infectious fever about procalcitonin (PCT),endotoxin (ET) and G test in the intensive care cancer patients.Methods:We included187cases of ICU patients with malignant fever, according to body fluids and secretions specimen bacterial culture,fungal culture and blood culture results,they were divided into control group,bacterial infection group,fungal infection group;In the bacterial infection’s group,according to the results of bacterial culture site,they were divided into two parts.Compared with the control group,we will find the quantitative differences in the levels of procalcitonin, endotoxin;In the fungal infection’s group,according to the results of fungal cultures,they were divided into two parts: systemic fungal infection and local fungal infection;Compared it with control group,we will find the quantitative differences in the levels of procalcitonin and G test.Results:In the group of bacterial infection,systemic infection,or local infection,compared with the control group, PCT, ET detection was significantly increased,the difference was statistically significant (P<0.001),and compared with local infection,the systemic infecter’s PCT, ET detect significantly increased,the difference was significant (P<0.001); in the fungal infection’s group, local infection,or systemic infection compared with the control group, PCT,G test detection was significantly increased,the difference was statistically significant (P<0.001);infection compared with the control group.G test detection in systemic infection’s group was significantly increased, the difference was significant (P<0.001).Combining detection of PCT and ET to find bacterial infection,has further improved the detection rate of bacterial infection,especially the detection of gram-negative bacteria infection.Also,the sensitivity and specificity will be greatly improved,and the negative predictive value and diagnostic index increased significantly. The detection rate is as high as98.49%.Combining detection of PCT and G test to find fungal infections,the sensitivity of detection of invasive fungal infection has further improved,the occurrence of the false negative has reduced.The detection rate is as high as 97.03%.Conclusion:Detecting PCT, endotoxin and G test is rapid, sensitive.They are of malignancy as early identification of infectious fever (bacterial infection or fungal infection) and non-infectious fever.