The Empirical Research On The Cases Of Professor Jin Shi Treating Chronic Liver Diseasebased On Data Mining

Purpose:The purpose of this lecture is to Inherit and dig the clinic thinking of the old Chinese Professor Jin Shi’s diagnosis and treatment of chronic liver disease in a better way,analysis and summarize his drug experience objectively. So that the clinical treatment can be guided better and the clinical experience can heritage better.Method:First,collecting Professor Jin Shi’s diagnosis of chronic liver disease medical records,and proofing the original medical records pictures. Second,Collecting management data by the CangGong clinic system,then preprocessing the satisfactory cases. Third,using Medcase V3.2CangGong clinics State of recording pulse pattern data mining system,then using data mining strengthen association rules operational model,Medcase Record Mining Systems,Association Rule Analysis platform,Xminer Operation Tool computing tools and enhanced FPGrowth algorithm,then based on the analysis results from the data mining,to analyze and summarize the various medical cases of chronic liver disease on symptoms,syndromes, pathogenesis, prescription drugs,etc,so that Professor Jin Shi clinical experience in the treatment of chronic liver disease can be explored.Results:1.Common symptoms of chronic liver disease are:fatigue,the right side of the body pain,epigastric pain,right flank pain, yellow eyes,yellow urine,dizziness,dry eyes,dry mouth,thin white fur,yellow fur.fur greasy,red tongue,dark tongue,thready pulse or string or slippery,dry eyes-dry mouth,Fatigue-mild weakness,yellow eyes-yellow urine ect,those are closely associated symptoms.2.The common pathogenesis of chronic liver disease are:damp heat and toxic mixed,liver and spleen disorders,hot and humid Accumulation,liver and spleen dystrophy,liver and kidney deficiency,liver and gallbladder catharsis Division lost,stagnation of liver-QI with deficiency of the spleen,the energy deficiency and the evil stay,QI stagnating in middle-JIAO,blood stasis,etc.3.The common pattern of syndromes of chronic liver disease are:syndrome of heat toxin stagnation,syndrome of dampness-heat of liver and gallbladder,syndrome of Liver and spleen deficiency,syndrome of lingering pathogen due to deficient vital qi,syndrome of yin deficiency of liver and kidney,syndrome of Liver stagnation and spleen deficiency,syndrome of liver and qi stagnation,syndrome of Accumulation of blood stasis,etc. 4.The comment treatment rule of Professor Jin Shi used to treat chronic liver disease are: Regulate the liver and spleen,eliminate heat and dampness,eliminate heat and detoxification, disperse blood stasis and dredge collateral,neutrally supplements the liver and kidney,harmonious liver and stomach,disperse stagnated liver qi and promote bile flow,etc.5.The common couplet drugs associated with chronic liver disease syndromes are:scutellaria and turmeric,scutellaria and sarmentosum,scutellaria and fried bupleurum,scutellaria and rhizoma pinellinae praeparata,fried bupleurum and rhizoma pinellinae praeparata.6.The result of drugs associate with chronic liver disease syndromes:syndrome of heat toxin stagnation with Solanum nigrum,fried Bupleurum,rhizoma pinellinae praeparat. syndrome of liver and qi stagnation associated with fried bupleurum. syndrome of Accumulation of blood stasis is closely related with salvia. hyperactive of liver syndrome is closely related with fried bupleurum,scutellaria and uncaria. Gallbladder relieving muggy syndrome associated with giant knotweed closely.7.Results of Chronic liver disease pathogenesis associated with drug:heat toxin stasis closely related with Solanum nigrum. Positive imaginary and bad energy stay is highly related with Solanum nigrum,fried Bupleurum,rhizoma pinellinae praeparat,herba hedyotis diffusae,turmeric,skullcaphigh.liver and qi stagnation syndrome has a high relationship with fried Bupleurum. Spleen phlegm has a higher degree of relationship with skullcap. Bile stasis has a higher degree of confidence associated with capillary artemisia.8.The drug that Professor Jin Shi uses frequently to treat chronic hepatitis B are:licorice, skullcap,fried Radix,sarmentosum,turmeric,France Pinellia,herba hedyotis diffusae,Solanum nigrum,Ligustrum lucidum,Amomum and other drugs. The drug has a high confidence with chronic hepatitis are:Fried Radix,Solanum nigrum,skullcap,France Pinellia,herba hedyotis diffusae,turmeric,etc.The drug that used frequently to treat chronic hepatitis C are: licorice,Scutellaria,fried Radix,turmeric,sarmentosum,Ligustrum lucidum,forsythia,gardenia,wormwood,Citrus aurantium,etc. And Solanum nigrum,wormwood,fried Bupleurum,Scutellaria,herba hedyotis diffusae,turmeric,etc,has a higher relevance with this disease.Drugs that have a high frequency to treat fatty liver are:skullcap,licorice,fried Radix,sarmentosum,turmeric,France Pinellia,Alisma,Citrus aurantium,loosestrife,turmeric,etc. And skullcap and fried Radix have a higher relevance with this disease. Drugs that have a high frequency to treat PBC are:skullcap,sarmentosum,friedRadix,Radix,licorice root,turmeric,forsythia,loosestrife,Citrus aurantium,wolfberry,ect. And Capillaris,red peony,Chinese wolfberry,Radix,Gardenia,loosestrife,turmeric have higher relevance with this disease.Drugs that have a high frequency to treat Cirrhosis are:licorice,Scutellaria,fried Radix,turmeric,sarmentosum,Citrus,France Pinellia,Ligustrum lucidum,Amomum,forsythia,etc. And fried Radix,Solanum nigrum, worm wood, skullcap,France Pinellia,herba hedyotis diffusae,turmeric have a higher relevance with this disease.9.The drug that professor JinShi uses frequently to treat ALT positive in patients with chronic liver disease was:licorice,Sedum sarmentosum,scutellaria,fried Bupleurum,turmeric,fructus ligustri lucidi,rhizoma pinellinae praeparat,forsythia,bitter orange,Radix Pittospori,etc.Drugs that have a higher frequency on treatment in patients with positive chronic liver disease AST are: licorice,radix scutellariae,hanging pot,fry radix bupleuri,radix curcumae,fructus ligustri lucidi,forsythia,Chinese wolfberry,pinellia,bitter orange,dwarf lilyturf,etc.Drug used frequently on treatment in patients with positive chronic liver disease TB are:licorice,radix glycyrrhizae,radix scutellariae,radix bupleuri,radix curcumae,hanging pot grass,wormwood,bitter orange,plantain,forsythia,Fried Gardenia,Cape Jasmine Fruit,desmodium etc;Treatment of chronic liver disease in HBV-DNA positive:licorice,skullcap,fried Radix,sarmentosum,turmeric,law Breit,Solanum nigrum,Phyllanthus,Ligustrum,orange peel,Amomum,fried Gardenia,forsythia,gardenia and other drugs appeared higher frequency.Conclusion:1. Heat,poison,wet,depression,blood stasis and other evil invasion of the liver and spleen,often caused by liver and spleen disorders,or liver and spleen dystrophy. The pathological nature of chronic liver disease associate with deficiency and excess and intermingled deficiency and excess factors. The sthenia pathogenic factors has damp and hot,blood stasis,muggy and hot toxin,and qi stagnation,etc. Asthenic disease include Qi deficiency, yang deficiency,blood deficiency,yin deficiency,ect.2. Professor Jin Shi’s treatment of chronic liver disease is given priority to with syndrome differentiation. The common syndromes of chronic liver disease include:syndrome of heat toxin stagnation,syndrome of dampness-heat of liver and gallbladder,syndrome of Liver and spleen deficiency,syndrome of lingering pathogen due to deficient vital qi,syndrome of yin deficiency of liver and kidney,syndrome of Liver stagnation and spleen deficiency,syndrome of liver and qi stagnation,syndrome of Accumulation of blood stasis, etc.3. Various types of chronic liver disease and related therapies machine features include:Pathogenesis of chronic hepatitis B,mostly heat Ecchymosis each node,liver,spleen and kidney three dirty damaged.Pathogenesis of chronic hepatitis C is the major toxic heat stasis dampness inside volts,liver and spleen damage.To clean,sparse,transportation, technology are up for the mainly method. Non-alcoholic fatty liver disease pathogenesis is qi,the hot junction,stagnation,phlegm,blood stasis infestation,liver and spleen disorders,treatment with clean dampness is characterized;Pathogenesis of liver cirrhosis is characterized by wet,hot,depression,drugs,etc. Accumulation liver and spleen,resulting in liver,spleen and kidney dysfunction,blood and qi stagnation,liver,spleen and kidney deficiency,treatment to eliminate stasis disease,transport the liver and spleen,etc. Pathogenesis of primary biliary cirrhosis of the liver and gallbladder poor critical,bile stasis network,treatment of gallbladder and network-based.4.Professor Jin treat liver disease focus on macro grasp the overall treatment,combination of disease and syndrome differentiation,as well as refer to the physical and chemical test results.In qing dynasty,hydrophobic,transport,and for the law,according to condition of the disease,combine with the application,according to clean,hydrophobic,transport,defuse,nourishing to cure the disease.Herbal Prescription on TCM drugs to the main way,and the different diseases have different medication. Such as the treatment of viral hepatitis Saka Solanum nigrum,herba hedyotis diffusae and other drug detoxification works well. The treatment for PBC often uses Saka wormwood,peony,turmeric. They can loose liver and vein. As for the treatment of nonalcoholic fatty liver,Alisma soup and drain turbidity can reduce lipid.5.Data mining can effectively summarize and refine old TCM treatment rule and drug laws, so that the experience of old TCM becomes more intuitive,easy to understand,the operator has a repeatability. It has an important significance of old TCM inheritance as well as the development and innovation of experience in medicine.