The Preliminary Cognitive Function Investigate Of People Who Experienced Malnutrition In Early Life

Background: The morbidity and mortality of Alzheimer’s diseaseincreases continuously, and China is gradually transformed to an agingsociety. How to early detection, diagnosis and treatment Alzheimer’sdisease, and improving the life quality of the elderly, reducing the mortalityand disability, will be the focus of social attention. More and more studiessuggested the rationality of “The Developmental Origins of Health andDisease, DOHaD”. Some researches have shown that early malnutrition isclosely relate to cognitive dysfunction of offspring. People whoexperienced the three years of natural disasters in the history of ourcountry(1959-1961), are generally exposed to early malnutrition. Therefore,to investigate the cognitive function of them, is helpful to clear the impactof early malnutrition on cognitive function.Purpose: To research the cognitive level of people who wereexperienced malnutrition in early life of the Chinese Great Fame (1959-1961), and discuss its possible influencing factors.Method: We recruited health adults who voluntarily accept theinvestigation from Physical examination center of the first affiliatedhospital of chongqing medical university during October2013to March2014.We defined people who were born during natural disasters years(1960.1.1—1961.12.31) as the group of fetal experienced malnutrition inearly life (G2).and people born before the natural disasters years（1957.1.1—1958.12.31） as the group of infants and young childrenperiod of experienced malnutrition in early life (G1),then defined peoplewho were born after the natural disasters（1963.1.1—1964.12.31） as noexperienced malnutrition in early life group(G3). We exclusion people whowith body or mental illness that may lead to brain function disorder. AndFor eligible respondents, we performed the questionnaire survey,determination of the scale, and collect the dates of routine test project. Weusing SPSS17.0examined the differences of affecting factors from the3groups through the single factor analysis of variance or rank sum test, andthen adopt multi-factor Logistic regression analyses to pinpoint theinfluence of various factors on cognitive function.Result:(1) All subjects classified by exposed malnutrition in differenttime, cognitive function score of G1is MMSE28.68±1.06、MoCA26.79±1.17，cognitive function score of G2is MMSE28.53±1.27、MoCA26.47±1.25，cognitive function score of G3is MMSE29.23±0.89、MoCA 27.44±1.09，MMSE scores between the three groups P is0.002, MoCAscore P is0.000，the difference there was statistically significant;(2) Allsubjects classified by cognitive function score, multi-factor logisticregression analysis: experienced malnutrition in fetal period, high LDLlevels, smoking history, introverted and not good at learning and thinking isan important factor in cognitive function.Conclusion: The population experienced malnutrition in early life hashigh risk of cognitive impairment than those without exposure tomalnutrition. And the group of fetal exposure to famine years is moreobvious in cognitive dysfunction. It is good for improving cognitive levelto fetal exposed to malnutrition as reducing LDL levels, no smoking,developing optimistic personality, and cultivating good habits of studyingand thinking.