Analysis Of15Cases Of Bartter Syndrome In Chidren

Objective: To investigate the clinical manifestations, diagnosis,treatment and prognosis of Bartter syndrome in children by analysis ofpatient cases and review of pertinent literature, for increasing awareness ofpediatricians, as well as improving prognosis and quality of life.Methods: Clinical data of15patients with Bartter syndrome treatedin Children`s Hospital Affiliated to Chongqing Medical University between2009-2014was analyzed, while a regular follow-up continued, in order toinvestigate the clinical manifestations, diagnosis, treatment and prognosis ofBartter syndrome in children.Results: Bartter syndrome is a kind of autosomal recessive inheritedrenal disorder which has been characterized by the association ofhypokalemia, hypochloremia, metabolic alkalosis, vomiting, growthretardation, the activation of the renin-aldosterone axis and normal bloodpressure. While clinical feature is always typical, genetic analysis is the mostreliable way to diagnose. Comprehensive therapy with antisterone,ibuprofen, catopril and potassium have remarkable effect on improvingclinical manifestations, growth retardation and quality of life. Conclusion: Bartter syndrome should be considered if children haveunreasonable continuous hypokalemia, hypochloremia, metabolic alkalosisand growth retardation. It can be clinical diagnosed by clinical manifestationand laboratory tests, while genetic analysis is the most reliable way. It can beameliorated by potassium and magnesium supplementation, antialdosteronemedications, prostaglandin inhibitors and antisterone. Considering thefollowing electrolyte disturbances, infections, growth retardation, kidneyfailure and even death, children with Bartter syndrome need lifelongtreatment, while early diagnosis and treatment is the most important.