Bartter Syndrome: A Case Report And Review

Objective To report a case and to review the literature of Bartter syndrome, including its epidemiology, pathogenesis, clinical symptom, diagnosis and treatment. To get the experience of the diagnosis and treatment of Bartter syndrome. Methods The clinical data of a patient from the 1th afficated hospital Guangxi Medical University was described and the pathogenesis, clinical symptom, diagnosis, treatment were analysed. Results Bartter syndrome encompasses a variety of disorders of renal tubular transport. It's causes conclude inborn and acquired. The former is a autosome recessive, the latter is got from other kidney diseases or other diseases. This syndrom can be divided into three different clinical entities: Neonatal Bartter syndrome,"Classic"Bartter syndrome and Gitelman syndrome. The mutated genes include: NKCC2 gene,ROMK gene,ClC-Kb gene,NCCT gene,BSND gene and CaSR. Bartter syndrome of acquired can be seen frequently on the adult. Combined therapy is effective for the patients of Bartter syndrome. The patient we report has the symptoms: hypokalemia, metabolic alkalosis, increase of renin, angiotensionâ…¡and aldosterone but normal tension. But renal biopsy isn't characterized by hyperplasia of the juxtaglomerular complex. Yet, the diagnosis of Bartter syndrome can be formed. The patient is 58 years old and has urinary tract infection for twenty years. As for the entity of this syndrome, Bartter syndrome of secondary has the most chance for the patient. The patient has recovered by the use of potassium,potassium-sparing diuretics,cyclooxygenase inhibitor and anti-infection. From the follow-up visiting ,we can see after the combined therapy, the effect of the use of potassium is good for the patient. Conclusion Bartter syndrome can be found in all the ages. The patient of...