The GGCX Gene Polymorphism And The Relationship On Warfarin Stable Dosage In Xinjiang Han Nationality

Objective:To study if The Correlation between GGCX gene polymorphism and the relationship on warfarin stable dosage in Xinjiang han nationality with atrial fibrillation (Atrial Fibrillation AF). Methods:The blood was collected from200han nationality people who live in Xinjiang for long time and have atrial fibrillation, DNA was extracted, polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP) was used and identified by agarose eletrophoresis to analyse GGCX genotype and allele distribution. Result:GGCX gene CC, CG and GG gene type frequency we-re found respectively82.5%,16.5%and1%, and C and G allele frequency were99%,1%.The GGCX (rs11676382) allele and genotype frequencies of selected crowd were the Hardy-Weinberg balance (Χ2=0.744, P=0.388). The subject on a stable dose range was1.25±6.875mg/d, mean3.22±1.12mg/d, The genotype of them were CC:5.93±1.33mg/d, CG:3.22±0.88mg/d and GG:3.16±1.14mg/d.The Kruskal-Wallis test analysis:GGCX (rs11676382) polymorphisms were significantly associated with warfarin stable dose (Χ2=6.094, P=0.047). Conclusion:Obtained GGCX gene rs11676382polymorphism of xinjiang han patients with atrial fibrillation. Also found that warfarin high doses associated with genotype CCGG and low-dose-related. This can be used as an indicator to predict an individual stable doses of warfarin.