| Objective:We want to observe the effect of replenish qi and nourishing blood recipe in treating fatigue caused by chemotherapy of colorectal cancer patients and find the mechanism of this therapy. We also want to analysis the advantage and feature of TCM treatment in relieving fatigue caused by chemotherapy of colorectal cancer patients.Methods:Randomized control study method was used to divide therapy group and control group.65cases of colorectal cancer chemotherapy patients were divided according to inclusion criteria into2groups, therapy group were given replenish qi and nourishing blood recipe after4circles mFolfox6regimen chemotherapy, control group were not given TCM after chemotherapy. We observed the degree of fatigue by Piper fatigue scale according to action/severity, emotion, sensation, and cognition/mood. We observed other symptoms by TCM score system once a week for4weeks. We use t test, Fisher’s test and x2test for analysis the status of patients to confirm the2groups have the similar background. We use t test for scale and TCM symptom score analysis. We use the nonparametric Wilcoxon rank sum test for effect analysis. We use SPSS19.0for the whole statistical analysis.Results:The fatigue severity and TCM symptom score increased in both2groups after chemotherapy, but the score in treatment group is lower than it in control group.(1) Piper fatigue scale:After1week the fatigue degree change of2groups is not significant.(P>0.05) After2weeks,the scale score (CRF) of control group is higher than treatment group.(P<0.05) After4weeks,the scale score (CRF) of control group is also higher than treatment group.(P<0.01) In the scale, the action/severity have more change than the,emotion, sensation, cognition/mood.(P<0.05) The CRF curves in2week and4weeks (chemotherapy intermission) are more flat than the curves in1week and3weeks (chemotherapy time).(2) TCM symptom:After1week, the change after therapy is significantly different between2groups in the symptom scores of spiritlessness, weak, spontaneous perspiration, laziness to speak, dizziness, hand hemp and pulse.(P<0.05) But facial expression, palpitation, insomnia, menstruation and the tongue showed no significant difference.(P>0.05) After2and3weeks the TCM symptoms showed more significant difference in palpitation, insomnia, menstruation and the tongue.(P>0.05) After4weeks the effective rates between2groups showed significant difference.(P<0.01) Conclusions:Replenish qi and nourishing blood recipe can significantly improve the fatigue caused by, reduced the incidence and severity of cancerous fatigue after chemotherapy of colorectal cancer patients, improve the quality of life in cancer patients. |
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