The Establishment Of Dynamic Pupil Measurement And Objective Assessment Of Anxiety And Depression In Patients With Coronary Heart Disease

ObjectiveTo establish dynamic pupil measurement, observe and analyze thepupilary changes of patients with coronary heart disease (CHD) andevaluate their anxiety and depression so as to provide a reference index forthe clinical assessment of patients’psychology.Methods80cases of patients with diagnosed CHD (CHD group) and40casesof people with non-CHD and no anxiety or depression (control group) wereselected for this study. The psychological and mental conditions of allsubjects were evaluated by using self-rating anxiety scale (SAS) andself-rating depression scale (SDS). The CHD group were divided intoanxiety-depression group(40cases) and non-anxiety-depression group(40cases). All pupil videos of all subjects were analyzed their pupil and irisdiameters and the ratio of both diameters with image analysis software andthen scores for SAS and SDS and the ratio of pupil and iris diameters were statistically analyzed.Results1.Dynamic pupil measurement has been established and isrunning well.2.The SAS scores of the control, anxiety-depression andnon-anxiety-depression groups were (30.45±3.47) points,(49.15±5.90)points and (29.00±3.95) points. The SAS score in the anxiety-depressiongroup were higher than that of the non-anxiety-depression group and thedifference was statistically significant (p <0.01). The SDS score of theanxiety-depression group was higher than both the non-anxiety-depressiongroup (49.7±5.61) and the control group (26.20±3.68) and thedifferences were statistically significant (p <0.01).3.The ratio of pupil and iris diameters in the anxiety-depression groupwas (0.47±0.05), higher than the control group (0.37±0.06) and thenon-anxiety-depression group (0.42±0.07) and the differences werestatistically significant (p <0.05). The ratio of non-anxiety-depressiongroup was higher than that of the control group and the differences werestatistically significant (p <0.05).4.There were differences in ratio distribution of pupil and irisdiameters and their curve shapes. The ratio distributions of the controlgroup, the non-anxiety-depression group and the anxiety-depression groupwere respectively between0.31and0.40,0.41and0.50,0.46and0.55. The peak numbers of the curve shapes in the control, non-anxiety-depressionand anxiety-depression groups ranged respectively between0.36and0.40,0.41and0.45,0.46and0.50.5. Pearson correlation analysis showed that scores for SAS and SDShad a positive correlation and the correlation coefficient r was0.780, p<0.01.Conclusion1.The ratio of pupil and iris diameters of CHD patients with noanxiety or depression is higher than non-CHD patients with no anxiety ordepression.Patients with coronary heart disease have the dysfunction oftheir autonomic nervous system.2.The ratio of pupil and iris diameters of CHD patients with anxietyand depression is higher than CHD patients with no anxiety or depression,which suggests that anxiety and depression exacerbate the dysfunction ofthe autonomic nervous system in patients with coronary heart disease.3.Dynamic pupil measurement can evaluate anxiety and depressionin patients with coronary heart disease (CHD).