The Changes Of Inflammatory Factors And Psychologi-Cal State In Patients With Coronary Heart Disease Combined With Anxiety/depression Before And After PCI

Purpose:To explore the effects and relationship of inflammatory factors and psychological state in patients with coronary heart disease combined with anxiety/depression before and after PCI.Methods:We selected80patients with established CHD in our hospital of Cardiology from April2012to December2012, who were divided inio two groups with or without PCI(forty patients in each group). All subjects were divided into PCI with anxiety and depression group (A), PCI without anxiety and depression group (B), coronary heart disease with anxiety and depression group (C) and coronary heart disease without anxiety and depression group (D) by me and a psychiatrist in our hospital We used the anxiety and depression scales to evaluate the state of mind of all researchers. Four groups of patients were exsanguinated of peripheral venous blood on the next morning fasting and one day after PCI (control groups on one day after coronary angiography) to assess the serum levels of high-sensitivity C-reactive protein (Hs-CRP) and interleukin-18(IL-18). Two weeks after surgery, all patients with coronary heart disease were evaluated the psychological state of anxiety and depression scale, then compared the difference of four groups and analysised of the relationship between them.Results:(1) The serum levels of Hs-CRP、IL-18after PCI were significantly higher than before PCI in A group and B group (P<0.01). The serum levels of Hs-CRP、IL-18were not statistically significant difference (P>0.05) before and after coronary angiography in C group and D group.(2) Pearson correlation analysis showed that the four anxiety/depression scales had a positive correlation with Hs-CRP and IL-18(P>0.05), and had not associated with age, BMI, TG, TC, LDL-C and HDL-C (P>0.05).(3) Selected80cases in patients with coronary heart disease combined with anxiety、depression and both of them were16cases (20%),12cases (15%) and8cases (10%) before PCI. There were20cases (25%),14cases (17.5%),6cases (7.5%) in patients with coronary heart disease combined with anxiety、depression and both of them after PCI. New patients with anxiety or depression were four cases and two cases after PCI.(4) The scores of Self-Rating Anxiety Scale, Self-rating depression scale, Hamilton Anxiety Scale and Hamilton Depression Scale were no significant differences(P>0.05) in patients with coronary artery disease before and after PCI.Conclusions:(1) The serum levels of Hs-CRP and IL-18in CHD patients are inereasing and even higher in those with anxiety and depression after PCI. This indicates that the body’s inflammatory response can be enhanced in CHD patients after PCI. The CHD patients who combined with anxiety and depression may be more active in the body’s inflammatory response after PCI.(2) There is still a large proportion of CHD patients combined with anxiety/depression after PCI, even the original patients without anxiety and depression are found to have anxiety and depression after PCI. This indicates that PCI does not improve patients of psychological and emotional disorders.(3) It’s nessary to give psychological treatment to CHD patients with anxiety and depression as soon as possible.