| Objective:Observe the curative effect of Shuanghe powder addition and subtraction' and'Kou's Yangxin guiding exercise' to treat coronary heart disease with anxiety and depression.Methods:? 60 subjects were selected by inclusion and exclusion criteria and divided into 3 groups,including 20 cases in trial 1 group,20 cases in trial 2 group and 20 cases in control group.? All patients were treated on the basis of the secondary prevention of coronary heart disease.The trial 1 group was treated with 'Shuanghe powder addition and subtraction combined with Kou's Yangxin guiding exercise'.The trial 2 group was treated with 'Shuanghe powder addition and subtraction combined with Regular physical exercise.The control group was treated with 'Lorazepam And Regular physical exercise'.Making the 'Shuanghe powder addition and subtraction' into granule,and taking it with boiled water twice a day for 1 month.Lorazepam was taken in conventional doses for 1 month and then gradually reduced.The subjects who practiced Kou's Yangxin guiding exercise' continued to exercise,the exercise frequency not less than 5 times a week,each time for 30 minutes to 1 hour,for 3 months.Subjects who performed Regular physical exercise chould choose to walk or ride,the exercise frequency not less than 5 times a week,each time for 30 minutes to 1 hour,for 3 months.Keep the heart rate within 120 beats/min during exercise.? Telephone follow-up was conducted weekly and On-site follow-up visits were conducted once a month for a total of 3 times,during the treatment period.Filled in anxiety and depression scale(including HAMD,HAMA,SAS,SDS),quality of life scale(SF-36),Pittsburgh sleep quality index(PSQI),Coronary Heart Disease of TCM syndrome classification quantitative table during the On-site follow-up visits.Statisticsed and analysised the changes between baseline and last follow-up of each scale.Results:? Baseline comparison before treatment:there were no significant difference(p>0.05)among the three groups of subjects in terms of gender,Age,comorbidity(including hypertensio,diabetes,hyperlipidemia),blood lipid examination(total cholesterol,triglycerides,low density lipoprotein),fasting blood glucose,electrocardiogram examination,BNP,6-minute walk test,Brog sensory score,comparable.? Three groups of treatment programs all have good curative effect and all the subjects improved in the anxiety and depression scale score,sleep quality,quality of life and symptoms of TCM,after treatment and exercise?Compared to baseline there was statistical difference(p<0.05).Trial 1 group had the best effect in every aspects,Trial 2 group had the middle effect,and the control group had the worst effect.? Comparison of baseline changes in the scores of the anxiety and depression scales(HAMD,HAMA,SAS,SDS)in the three groups after treatment:Baseline changes:There was a statistically significant difference in baseline changes over one months and three months,in comparison between the three groups(P<0.05).Comparison of baseline changes over one months between the groups:HAMD score:There was a statistically significant difference between the trial group 1 and the control group(P<0.05).HAMA and SAS scores:There was a significant difference between the three groups(P<0.05).In terms of SDS scores,there was a significant difference between the trial group 1 and the other two groups(P<0.05).Comparison of baseline changes over three months between the groups:HAMD score:There was a significant difference between the trial group 1 and the other two groups(P<0.05).HAMA scores:There was a significant difference between the three groups(P<0.05).SDS scores:There was a significant difference between the trial group 1 and the control group(P<0.05).In terms of SAS scores,there was a significant difference between the control group and the other two groups(P<0.05).? Comparison of baseline changes and efficacy of the Pittsburgh Sleep Quality Index(PSQI)scores after treatment in the three groups:Baseline changes:There was a statistically significant difference in baseline changes over one months or three months,in comparison between the three groups(P<0.05).Comparison of baseline changes over one months between the groups:There was a significant difference between the trial group 1 and the other two groups(P<0.05).Comparison of baseline changes over three months between the groups:There was a significant difference between the control group 1 and the other two groups(P<0.05).Efficacy:compared the total effective rate of the three groups,there was a statistical difference(P<0.05).The trial group 1 had the best effect,the trial group 2 had the better effect,and the control group had the worst effect;There was a statistically significant difference in the efficacy between trial group 1 and the other two groups(P<0.05).? Comparison of Baseline Changes of the Short Form 36 Health Survey Questionnaire(SF-36)scores of the three groups after treatment:Baseline changes:In comparison between the three groups,in the one-month baseline change,there were statistical differences between the three groups,in terms of Physical Functioning,Role-Physical,Vitality,Role-Emotional and Mental Health(P<0.05).For the three-month baseline change,there was a statistically significant difference in the baseline change of two factors(Role-Physical and Role-Emotional)among the three groups of subjects(P<0.05).There was no significant difference in baseline changes of other factors(P>0.05).Comparison of baseline changes over one months between the groups:Physical Functioning and Role-Physical factors:There was a significant difference between the trial group 1 and the control group(P<0.05).Vitality factor:There was a significant difference between the three groups(P<0.05).Role-Emotional and Mental Health factors:There was a significant difference between the control group 1 and the other two groups(P<0.05).Comparison of baseline changes over three months between the groups:Role-Physical and Role-Emotional factors:There was a significant difference between the trial group 1 and the control group(P<0.05).? Comparison of baseline changes and efficacy of TCM syndrome classification and quantification table of coronary heart disease in three groups after treatment:Baseline changes:here was a statistically significant difference in baseline changes over one months and three months,in comparison between the three groups(P<0.05).Comparison of baseline changes over one months between the groups:There was a significant difference between the trial group 1 and the other two groups(P<0.05).Comparison of baseline changes over three months between the groups:There was a significant difference between the trial group 1 and the control group(P<0.05).Efficacy:compared the total effective rate of the three groups,there was a statistical difference(P<0.05).The efficacy of the trial group 1 was the best,the trial group 2 was the better,and the worst was the control group;There was a statistically significant difference in the efficacy of trial group 1 between the control group(P<0.05).Conclusions:trial group 1(Shuanghe powder addition and subtraction combined with Kou's Yangxin guiding exercise)was better than those of the other two groups in baseline changes of the anxiety and depression scale(HAMD,HAMA,SAS,SDS)scores,baseline changes and efficacy of the Pittsburgh Sleep Quality Index,baseline Changes of the Short Form 36 Health Survey Questionnaire(SF-3 6)scores in physiological function and emotional function facter,baseline changes and efficacy of TCM syndrome classification and quantification table of Coronary Heart Disease.The study suggests that Shuanghe powder addition and subtraction combined with Kou's Yangxin guiding exercise can significantly reduce the level of anxiety,depression,improve sleep quality and quality of life,and improve symptoms of traditional Chinese medicine. |
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