The Correlation Between The Serologic Level Of Lipid And Parkinson’s Disease And Alzheimer Disease

Objective:To evaluate levels of blood lipid in patients with PD and AD and toexplore whether blood lipid level is associated with the initiation of PD andAD.Methods:Sixty-two patients with PD and fifty-three patients with AD from2005to2013were enrolled.In addition50cases of normal persons withmatched age and sex were taken as the control group.Levels of blood lipidin each group were accessed.Results:No significant difference in levels of TC,TG,HDL-C,LDL-C andApoB between PD group and control was observed (p<0.05).levels ofApoA1were significantly decreased in PD group compared with that fromcontrols (p>0.05).Compared with controls,levels of TC,LDL-C and ApoBwere dramatically increased and ApoA levels were significanfly decreasedin AD group (p<0.05).However,there is no obvious difference in TG, HDL-C and ApoA1levels between AD group and control (p>0.05).Conclusion:Patients with PD and AD have lipid metabolism disorder comparedwith normal controls.The mechanism by which aberrant lipid levels play arole in the progression of AD and PD is needed to be further validated.