The Levels Of Lipid And Homocysteine In Alzheimer’s Disease

Objective: Alzheimer’s disease (AD) is a progressive neurodegenerative disorderand the most common form of dementia.But the Pathological mechanism keepsunknown.Many studies have shown that vascular risk factors can promote the progressof AD, Serum LiPid and Homocysteine included, but the result is not consistent.In thisstudy,we detected the levels of triglycerid(TG）、total cholesterl(TC）、HDL-C、LDL-C、lipoprotein（a）and homoeysteine in AD and controls in order to investigate its changesin Alzheimer’s disease.Methods: There are30patients with Alzheimer’s disease and27healthy subjects.All the patients were collected from the First Affiliated Hospital of Dalian MedicalUniversity,and meet the AD probably diagnostic criteria which made by theNINCDS-ADRDA. All research objects were measured by MMSE. All healthy controlshave no obvious memory impairment, MMSE score>26points, no serious medicaldisease,such as heart, liver and kidney, blood disorders, severe alcoholism andneurological or psychiatric disorders. Two neurology physicians conducted clinical datacollection, including the history collection, physical examination and assessment ofdementia scale of nervous system,for AD and healthy control group together.The dataswere analyzed by SPSS20.0statistics package,and probability value was consideredsignificant when＜0.05.Results：Serum TC levels were significantly higher in AD（198.63±45.193mg/dl）than in healthy controls（171.85±29.063mg/dl P=0.01）. Serum LDL-C levels were alsosignificantly higher in AD （117.60±30.332mg/dl） than in healthy subjects（97.04±21.194mg/dlP=0.004）.But TC and LDL-C had no significant correlationwithMMSE scores respectively and had no significant differences in AD subgroup.There are no significant differences in serum triglycerid(TG),HDL-C,lipoprotein(α)andhomoeysteine between AD and controls,early and later AD patiences respective ly.Nocorrelation was observed between MMSE seores and serum triglycerid(TG）、HDL-C、lipoprotein（α）and homoeysteine,respectively.Conclusion:1. There are dyslipidemia in patients with AD，mainly for serum TCand LDL-C.2. serum TC and LDL-C has nothing to do with AD severity.3.This studyfound no abnormal homocysteine levels in patients with AD, and homocysteine levelshas nothing to do with the AD severity.