Analysis Of The Sex Hormone Abnormalities In Female Patients With Thyroid Dysfunction

Background and purposeThyroid disfunction is a kind of common chronic diseases, includinghyperthyroidism and hypothyroidism. The incidence rate ofhyperthyroidism is about0.5%. Hyperthyroidism can occur whatever youare a baby or an older man, while the peak is from20to40years old. Inrencently years, the incidence of hyperthyroidism is obviously increasingand different areas have different results. Data from UK estimated thatthe annual incidence rate in female is2%～3%, whereas it is1.6%inmale. While a Chinses epidemiological study indicated that the totalincidence rate was3%,4.1%in female,1.6%in male, and the sexualratio of hyperthyroidism patients was1:4～1:6.There are more Female with Hypothyroidism than male patients,and the incidence rate increases with age. The morbidity of subclinicalhypothyroidism is about7.5%～13.6%in female, and2.8%～5.7%inmale, the incidence rate of which is3.5:1000in female, and0.6:1000inmale.The effects of hyperthyroidism on female reproductive systeminclude infrequent menstruation, period elongation, even amenorrhea.The effects of hypothyroidism on female reproductive system includehypermenorrhea, menostaxis, infertility, severe functional uterinebleeding, and galactorrhea in one third patients.Therefore, hyperthyroidism and hypothyroidism are becoming agraet threat to the health of residents,especialy female. This paperanalyzed the levels of sexual hormone in64patients with hypothyroidism, 72patients with hyperthyroidism, and100controls, in order toinvestigate whether there are sexual hormones abnormality in femalethyroid dysfunction or not and the correlation between thyroid functionand sexual hormones, and to explore the changing regularity ofhypothalamus–pitumitary-gonad axis in patients with thyroiddisfunction.Methods64patients with hypothyroidism,72patients with hyperthyroidism,and100controls from the outpatient department and ward ofendocrinology were selected as cases of this study. Sreum levels ofFSH, LH, T, E2, PRL were detected by use chemiluminescentimmunoassay. by detected free triiodothyronine、 free thyroxine、thyroid-stimulating hormone and clinical feature with Hyperthyroidismor Hypothyroidism regard as Select standard.Results.In patients with Hypothyroidism,the serum levels ofT(0.4±0.43)ng/ml vs0.5±0.32)ng/ml, E2(46.33±9.83)pg/ml vs(50.81±9.64)pg/ml were lower than those in controls, the disparityhas statistical significance (P<0.05);While the serum levels ofFSH(10.13±1.22) uIU/ml vs (6.40±1.47) uIU/ml,LH （8.87±1.42)uIU/L vs (4.17±1.21)uIU/L and PRL(18.80±3.49) ng/ml vs(9.32±2.89) ng/ml were higher than those in controls, the disparityhas statistical significance (P<0.01);In patients with hyperthyroidism,the serum levels of FSH（8.20±1.10)uIU/L vs (6.40±2.80)uIU/L,T(0.90±0.41)ng/mlvs (0.5±0.32)ng/ml and PRL（16.41±2.89）ng/mlvs（9.32±2.89）ng/ml were higher than the controls, the disparity has statisticalsignificance (P<0.05); while the serum levels of LH(6.34±1.96) uIU/Lvs (4.17±1.21)uIU/L, E2(80.13±11.54) pg/ml vs(50.81±9.64)pg/mllevels were significantly higher than the controls,and the disparity has statistical significance (P<0.01).Conclusions1． FSH、LH、T、 E2、PRL have correlatin with sex hormoneabnormal in female patients;2． Thyroid dysfunction may cause the abnormality of thehypothalamic-pituitary-gonadal axis.