Tripterygium Wilfordii Clinical Research For The Treatment Of Diabetic Nephropathy Stage â…£

Objective:Diabetic nephropathy in clinical stage no special treatment, western medicine clinical practice concluded that treatment of Chinese medicine have their own characteristics and advantages, delay the renal function of progress, improve the quality of life of patients. In recent years, the tutor is committed to the exploration of phase IV clinical treatment of diabetic nephropathy. This topic is to mentor summary and analysis of clinical experience, whether treatment of glucoside tripterygium wilfordii joint basis as stage IV one of effective treatment of diabetic nephropathy. Bring the Gospel for more patients with diabetic nephropathy, provide an effective treatment way for physician.Methods:According to shenzhen hospital ShenBingKe outpatient and the inpatient cases of diabetic nephropathy patients with stage IV, strictly according to include and exclude the standard choice case, randomly divided into treatment group and control group two groups, respectively based on glucoside tripterygium wilfordii joint treatment (traditional Chinese medicine dialectical treats+symptomatic treatment) and basic treatment (traditional Chinese medicine dialectical treats+symptomatic treatment). Treatment is the same:the basis of two groups of patients with traditional Chinese medicine dialectical, making use of insulin to control blood sugar, with CCB, beta blockers, step-down. The treatment group is in the control group on the treatment of treatment with tripterygium wilfordii. In close determination of two groups of cases before and during treatment in patients with laboratory indicators. During treatment monitoring in patients with liver function, hemoglobin, serum creatinine, creatinine clearance,24h protein quantitative, low density lipoprotein cholesterol (hdl-c), C-reactive protein and blood sedimentation indicators. Statistics of two groups of3、6、9and12months of hemoglobin, serum creatinine, creatinine clearance,24h protein quantitative, low density lipoprotein cholesterol (hdl-c), the changes of C reactive protein and blood sedimentation.Results:1) Into groups of two groups of hemoglobin, serum creatinine, creatinine clearance,24h protein quantitative, low density lipoprotein cholesterol (hdl-c), C-reactive protein and blood sedimentation were no statistically significant difference (P>0.05), two groups of comparable.2) Two groups of curative effect, treatment group total effectiveness84.2%, show the efficiency of31.6%; The control group total effective rate66.7%, the efficiency is16.7%.3) Main laboratory index changes, the treatment group after6months of follow-up, the control group after nine months of hemoglobin compared with before each treatment was statistically significant.(P<0.05);The treatment group in the follow-up of12months, the control group after nine months of serum creatinine and creatinine clearance compared with before each treatment was statistically significant(P<0.05); Treatment group after3months of follow-up, the control group after nine months compared with before each treatment was statistically significant (P<0.05); Treatment group at follow-up9months after the low density lipoprotein, C-reactive protein and blood sedimentation compared with before treatment (P<0.05), the control group in the follow-up process in low density lipoprotein,-reactive protein and blood sedimentation compared with before treatment had no statistical significance (P>0.05).Conclusion1) Tripterygium wilfordii has obvious reduce albuminuria curative effect.2) Tripterygium wilfordii glycosides more hemoglobin in patients with diabetic nephropathy Ⅳ, low density lipoprotein cholesterol (hdl-c), C reactive protein and blood sedimentation regulation have certain effect.3) Tripterygium wilfordii glycosides union foundation treatment, can delay the diabetic nephropathy stage IV serum creatinine and creatinine clearance drop speed, delay the progress of renal function.4) Study confirms that tripterygium wilfordii glycosides union foundation treatment of diabetic nephropathy stage Ⅳ has obvious curative effect, as a new diagnosis and treatment plan because of the limitation of time and conditions remains to be further multicenter, randomized, double-blind study confirmed.