A Retrospectively Study About The Nephrotic Syndrome Pathological Type Characteristics And Prognosis Of Guangdong Provincial Hospital

Objective:A retrospective analysis about PNS pathological types, symptoms, laboratory findings and prognosis alleviate of our hospital’s patients, Advantage composition ratio statistics PNS while comparing different treatment regimens, especially in the medical treatment of the disease where the advantage for future clinical physicians provide an initial basis for standardization of medical treatment PNS diagnosis of the disease as well underway.Methods:A retrospective analysis of clinical research methods, to our hospital pathology department, inpatient and outpatient system database as the basis, in accordance with the uniform diagnostic criteria, inclusion criteria and exclusion criteria. According to their regimen, thwew were included319cases of primary nephrotic syndrome which immunosuppressant group of83patients, medicine intervention group231cases. The research collects patients’ information, observates patients after six months of treatment, serum albumin,1year,2years,24-hour urinary protein excretion, serum creatinine, triglycerides and changes in clinical symptoms. Results:1.The distribution of patients with pathological type1. Statistics Guangdong Provincial Hospital of primary nephrotic syndrome and found that included319cases of PNS patients, membranous nephropathy (MN) occupy the maximum proportion of patients with a total of106cases (33.22%), followed in turn of minimal change nephrotic glomeruli (MCD)91patients(28.5%), focal segmental glomerular proliferative kidney disease (FSGS)69cases (21.61%), mesangial proliferative glomerulonephritis nephropathy (MsPGN)23patients (7.23%). IgA nephropathy with nephrotic syndrome in patients with clinical manifestations of23cases (7.14%), kidney mesangial capillary glomerulonephritis(MPGN)6cases (1.91%), other primary glomerular disease manifestations2cases (IgM nephropathy, etc.) as nephrotic syndrome, the proportion of less than0.50%. Institute may constitute cases of primary nephrotic syndrome associated with the proportion of basic monographs match.2. on the Chinese medicine group intervention group and immunosuppressant white blood cell count at different time points, serum albumin, serum creatinine, total cholesterol, improve significantly different(P>0.05), and each endpoint has improved after treatment3. hospital patients with primary nephrotic syndrome exists in the natural course of24cases of end-stage chronic kidney disease entering the proportion was7.5%, including kidney glomerular mesangial capillary worst prognosis, three cases (50.00%) patients into renal failure, followed by IgA nephropathy two cases(8.69%), membranous nephropathy8cases (7.55%), focal segmental proliferative kidney disease4cases (5.79%), minimal change disease five cases (5.49%), glomerular mesangial proliferative kidney disease1case (4.43%). Basically consistent with the existing relevant statistics. Chinese intervention in the treatment group6months,1year after, and24-hour urinary protein decreased after2years are better than the immunosuppressant group (P<0.05)4. Huang Kui Capsule relatively simple to use, as well as two three-stilbene oral combination therapy in patients with Chinese medicine24h urine protein, serum albumin, and prognosis remission can be found to ease the situation two kinds of Chinese medicine used in combination in patients with nephrotic syndrome significantly higher than the optimum use of two medicines alone. Conclusion:1. Primary nephrotic syndrome is one of the most common glomerular disease, hospital statistics I read the piece unified pathologist for seven years for all kidney patients pathological type and prognosis syndrome can be found in the most common clinical PNS membranous nephropathy and minimal change disease, focal segmental proliferative glomerulonephritis followed by kidney disease; prognosis for the kidney glomerular mesangial capillary most dangerous, I pathology prognostic differences, but the differences were not significant. Provide basic diagnosis is based on biopsy for clinicians choose the recommended biopsies before and after the treatment program.2. Clinical use of Chinese medicine treatment based on differentiation of primary nephrotic syndrome have a good effect. which on remission of clinical symptoms and reduce proteinuria, reduce creatinine rises, improve serum albumin, lipid-lowering and other effects on the early reduction of urinary protein excretion. It has obvious advantages shorten the primary nephrotic syndrome patients exposed to massive proteinuria time, to a certain extent, reduce the patient due to the immunosuppressive therapy medicine brings side effects, worthy of implementation and promotion.