Investigation Of The Recurrent Factors Of Cervical Cancer After Surgery

Objective: The report was to explore the recurrence factors of cervical cancerafter surgery, so as to provide methods for preventing and reducing the recurrence ofcervical cancer.Materials and Methods: A retrospective study of248cases of cervicalcancer patients in the Liu Zhou Worker,s Hospital from June2000to June2012. Allthe people,s data were full. All of those people had accepted operation in thishospital.The main operation method was radical correction.The adjuvant therapybefore surgery were chemotherapy and radiotherapy, and the treatment methods wereradiotherapy and chemoradiotherapy after surgery.Use SPSS19.0statistics software toanalyze the factors.The univariate factors usedχ2test,and the multivariate factors usedthe unconditioned logistic regression method to analyze, to confirm the risk factorsthose had relation with the relapse of the carcinoma of uterine cervix after surgery.Results:(1) Of the248cervical cancer cases,52patients relapsed,the relapse rate is21.0%.40patients relapsed during two years after operation, the2-years recurrent ratewas76.9%.38cases recurred in pelvic(vagina and parametrium)(73.1%),6casesdistant metastasis (11.5%).(2) Univariate factors analysis result showing:①.The recurrent rates have nosignificance between the people who were older35years or not,their relapse rateswere21.7%with16.7%(p>0.05);②. The recurrent rate of stageⅠB～ⅡA (17.6%)was significant lower than that of stageⅡB～ⅢA (36.3%)(P<0.05);③. The relapse rates were obviously different between low tissue differentiation or not, their relapserates were28.4%with16.3%(p<0.05);④. The relapse rates have obviously differencebetween the people whose tissue type were cervical squamous tumor or not, theirrelapse rates were34.1%、18.4%(p<0.05);⑤. The recurrent rates have statisticaldifference between the patients whose tumor size (≥4cm) or not, their relapse rateswere27.4%with15.3%(p<0.05);⑥. The relapse rates were obviously differentbetween the people those lymph node with tumor or not, their relapse rates were34.4%with12.9%(p<0.05);⑦. The recurrent rates have obviously differencebetween the patients who had deep cervical muscle layer infiltration (≥2/3) or not,their relapse rates were49.3%,10.1%;⑧. The relapse rates were statisticaldifference between the patients who vascular space involved or not, their relapse rateswere35.3%with15.6%;⑨. The recurrent rates have obvious difference between thecases those were positive surgical margin or not, their relapse rates were62.5%with19.6%;⑩. The recurrent rates have obvious difference between the people thoseparametrium involved or not, their relapse rates were50.0%with19.7%(p<0.05);.The recurrent rates have no obvious difference between the patients who acceptedadjuvant therapy or not before surgery;. The recurrent rates were obviouslydifferent between the people who accepted treatment or not after surgery, theirrecurrent rates were17.3%、40.4%(p<0.05); The relapse rates were not differentbetween the people who accepted radiotherapy and those who acceptedchemoradiotherapy after operation, their recurrent rates were22.2%、14.4%(p>0.05).(3) Multivariate factors analysis result showing: leading the above factors whohave statistical difference into the logistic regression analysis, the result showing:stage,tissue differentiation,tumor of size, lymph node wih tumor, postoperativeadjuvant therapy those five factors were the independent factors of the relapse ofcervical cancer after operation.Conclusion:(1) Clinical stage, tissue differentiation,tissue type,tumor size(≥4cm), lymphnode with tumor,deep cervical muscle layer infiltration (≥2/3), vascular space involved, surgical margin with tumor, parametrium infiltration， postoperativeadjuvant therapy were the factors those have relation with the relapse of the carcinomaof uterine cervix after surgery.(2) Clinical stage, tissue differentiation,tumor size(≥4cm), lymph node withtumor, postoperative adjuvant therapy were the independent factors for the relapse ofthe carcinoma of uterine cervix after surgery.(3) Postoperative adjuvant radiotherapy or chemoradiotherapy reduce the relapseof the carcinoma of uterine cervix after operation.